product summary
company name :
Hycult Biotech
product type :
antibody
product name :
Shigatoxin 1, mAb 13C4
catalog :
HM6007
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
13C4
reactivity :
Enterobacteria phage BP-4795
application :
western blot
more info or order :
Hycult Biotech product webpage
citations: 7
Reference
Lentz E, Leyva Illades D, Lee M, Cherla R, Tesh V. Differential response of the human renal proximal tubular epithelial cell line HK-2 to Shiga toxin types 1 and 2. Infect Immun. 2011;79:3527-40 pubmed publisher
Lentz E, Cherla R, Jaspers V, Weeks B, Tesh V. Role of tumor necrosis factor alpha in disease using a mouse model of Shiga toxin-mediated renal damage. Infect Immun. 2010;78:3689-99 pubmed publisher
Li R, Harada T, Honjoh K, Miyamoto T. Phylogenetic analysis and Shiga toxin production profiling of Shiga toxin-producing/enterohemorrhagic Escherichia coli clinical isolates. Microb Pathog. 2010;49:246-51 pubmed publisher
Wei F, Cao S, Ren X, Liu H, Yu J, Li H, et al. Efficient antiproliferative and antiangiogenic effects on human ovarian cancer growth by gene transfer of attenuated mutants of Shiga-like toxin I. Int J Gynecol Cancer. 2008;18:677-91 pubmed
McNichol B, Rasmussen S, Carvalho H, Meysick K, O Brien A. Two domains of cytotoxic necrotizing factor type 1 bind the cellular receptor, laminin receptor precursor protein. Infect Immun. 2007;75:5095-104 pubmed
Smith M, Carvalho H, Melton Celsa A, O Brien A. The 13C4 monoclonal antibody that neutralizes Shiga toxin Type 1 (Stx1) recognizes three regions on the Stx1 B subunit and prevents Stx1 from binding to its eukaryotic receptor globotriaosylceramide. Infect Immun. 2006;74:6992-8 pubmed
Smith M, Teel L, Carvalho H, Melton Celsa A, O Brien A. Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2. Vaccine. 2006;24:4122-9 pubmed
product information
Catalog no :
HM6007
Title :
Shigatoxin 1, mAb 13C4
Clone no :
13C4
Quantity :
100 µg
Application code :
functional studies,immunoassays,western blot
Host species :
mouse
Isotype :
IgG1
Conjugate :
purified
Aliases :
Verotoxin 1
Type :
mAb
Antigen :
Shigatoxin 1
Meta data :
Verotoxin 1, SLT, EHEC, Gb3
more info or order :
Hycult Biotech product webpage
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.