product summary
company name :
Hycult Biotech
product type :
antibody
product name :
L-Ficolin, Human, mAb GN5
catalog :
HM2091-IA
quantity :
0.5 mg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
GN5

The same clone is also sold as:
reactivity :
human
application :
western blot, immunoprecipitation
more info or order :
citations: 17
Reference
Brinkmann C, Jensen L, Dagnæs-Hansen F, Holm I, Endo Y, Fujita T, et al. Mitochondria and the lectin pathway of complement. J Biol Chem. 2013;288:8016-27 pubmed publisher
Brady A, Calix J, Yu J, Geno K, Cutter G, Nahm M. Low invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activation. J Infect Dis. 2014;210:1155-65 pubmed publisher
Krarup A, Sørensen U, Matsushita M, Jensenius J, Thiel S. Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin. Infect Immun. 2005;73:1052-60 pubmed
Matsushita M, Kilpatrick D, Shiraki H, Liu Y, Tateishi K, Tsujimura M, et al. Purification, measurement of concentration, and functional complement assay of human ficolins. Methods Mol Biol. 2014;1100:141-59 pubmed publisher
Degn S, Hansen A, Steffensen R, Jacobsen C, Jensenius J, Thiel S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J Immunol. 2009;183:7371-8 pubmed publisher
Dehus O, Pfitzenmaier M, Stuebs G, Fischer N, Schwaeble W, Morath S, et al. Growth temperature-dependent expression of structural variants of Listeria monocytogenes lipoteichoic acid. Immunobiology. 2011;216:24-31 pubmed publisher
Fust G, Munthe-Fog L, Illes Z, Széplaki G, Molnar T, Pusch G, et al. Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke. J Neuroinflammation. 2011;8:185 pubmed publisher
Brady A, Spencer B, Falsey A, Nahm M, Litwin V. Blood collection tubes influence serum ficolin-1 and ficolin-2 levels. Clin Vaccine Immunol. 2014;21:51-5 pubmed publisher
Hu Y, Luo F, Fu J, Chen T, Wu S, Zhou Y, et al. Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol. 2013;77:144-50 pubmed publisher
Wittenborn T, Thiel S, Jensen L, Nielsen H, Jensenius J. Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma. J Innate Immun. 2010;2:167-80 pubmed publisher
Zacho R, Jensen L, Terp R, Jensenius J, Thiel S. Studies of the pattern recognition molecule H-ficolin: specificity and purification. J Biol Chem. 2012;287:8071-81 pubmed publisher
Liu J, Ali M, Shi Y, Zhao Y, Luo F, Yu J, et al. Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to complement activation. Cell Mol Immunol. 2009;6:235-44 pubmed publisher
Fujieda M, Aoyagi Y, Matsubara K, Takeuchi Y, Fujimaki W, Matsushita M, et al. L-ficolin and capsular polysaccharide-specific IgG in cord serum contribute synergistically to opsonophagocytic killing of serotype III and V group B streptococci. Infect Immun. 2012;80:2053-60 pubmed publisher
Pan Q, Chen H, Wang F, Jeza V, Hou W, Zhao Y, et al. L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo. J Innate Immun. 2012;4:312-24 pubmed publisher
Aoyagi Y, Adderson E, Rubens C, Bohnsack J, Min J, Matsushita M, et al. L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway. Infect Immun. 2008;76:179-88 pubmed
Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, et al. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PLoS ONE. 2013;8:e73859 pubmed publisher
Hamad I, Christy Hunter A, Rutt K, Liu Z, Dai H, Moein Moghimi S. Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover. Mol Immunol. 2008;45:3797-803 pubmed publisher
product information
Catalog no :
HM2091-IA
Title :
L-Ficolin, Human, mAb GN5
Clone no :
GN5
Quantity :
0.5 mg
Application code :
immunoassays,immunoprecipitation,western blot
Species :
human
Host species :
mouse
Isotype :
IgG1
Conjugate :
purified
Type :
mAb
Antigen :
L-Ficolin
Meta data :
Ficolin-2, H-Ficolin, M-ficolin, MBL
more info or order :
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.