product summary
company name :
Hycult Biotech
product type :
antibody
product name :
LL-37/CAP-18, Human, mAb 3D11
catalog :
HM2070
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3D11
reactivity :
human
application :
western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 13
Published Application/Species/Sample/DilutionReference
  • ELISA; human
Boesch A, Zhao Y, Landman A, Garcia M, Fahey J, Wira C, et al. A multiplexed assay to detect antimicrobial peptides in biological fluids and cell secretions. J Immunol Methods. 2013;397:71-6 pubmed publisher
Ganguly D, Chamilos G, Lande R, Gregorio J, Meller S, Facchinetti V, et al. Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8. J Exp Med. 2009;206:1983-94 pubmed publisher
Cruse G, Fernandes V, de Salort J, Pankhania D, Marinas M, Brewin H, et al. Human lung mast cells mediate pneumococcal cell death in response to activation by pneumolysin. J Immunol. 2010;184:7108-15 pubmed publisher
Flick-Smith H, Fox M, Hamblin K, Richards M, Jenner D, Laws T, et al. Assessment of antimicrobial peptide LL-37 as a post-exposure therapy to protect against respiratory tularemia in mice. Peptides. 2013;43:96-101 pubmed publisher
Sakabe J, Umayahara T, Hiroike M, Shimauchi T, Ito T, Tokura Y. Calcipotriol increases hCAP18 mRNA expression but inhibits extracellular LL37 peptide production in IL-17/IL-22-stimulated normal human epidermal keratinocytes. Acta Derm Venereol. 2014;94:512-6 pubmed publisher
Shirin T, Rahman A, Danielsson A, Uddin T, Bhuyian T, Sheikh A, et al. Antimicrobial peptides in the duodenum at the acute and convalescent stages in patients with diarrhea due to Vibrio cholerae O1 or enterotoxigenic Escherichia coli infection. Microbes Infect. 2011;13:1111-20 pubmed publisher
Coffelt S, Waterman R, Florez L, Honer zu Bentrup K, Zwezdaryk K, Tomchuck S, et al. Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion. Int J Cancer. 2008;122:1030-9 pubmed
Wagener J, Mailänder-Sánchez D, Schaller M. Immune responses to Candida albicans in models of in vitro reconstituted human oral epithelium. Methods Mol Biol. 2012;845:333-44 pubmed publisher
Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee J, et al. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells. 2010;28:2229-38 pubmed publisher
Fathy H, Amin M, El-Gilany A. Upregulation of human β-defensin-3 and cathelicidin LL-37 in Kaposi's sarcoma. F1000Res. 2012;1: pubmed publisher
Li D, Wang X, Wu J, Quan W, Ma L, Yang F, et al. Tumor-produced versican V1 enhances hCAP18/LL-37 expression in macrophages through activation of TLR2 and vitamin D3 signaling to promote ovarian cancer progression in vitro. PLoS ONE. 2013;8:e56616 pubmed publisher
Hertting O, Holm A, Lüthje P, Brauner H, Dyrdak R, Jonasson A, et al. Vitamin D induction of the human antimicrobial Peptide cathelicidin in the urinary bladder. PLoS ONE. 2010;5:e15580 pubmed publisher
Turkoglu O, Kandiloglu G, Berdeli A, Emingil G, Atilla G. Antimicrobial peptide hCAP-18/LL-37 protein and mRNA expressions in different periodontal diseases. Oral Dis. 2011;17:60-7 pubmed publisher
product information
Catalog no :
HM2070
Title :
LL-37/CAP-18, Human, mAb 3D11
Clone no :
3D11
Quantity :
100 µg
Application code :
functional studies,paraffin sections,western blot,immunofluorescence
Species :
human
Host species :
mouse
Isotype :
IgG1
Conjugate :
purified
Aliases :
CAP-18
Type :
mAb
Antigen :
LL-37
Meta data :
CAP18, Cathelicidins, FPRL1, P2X7
more info or order :
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.