product summary
company name :
Hycult Biotech
product type :
antibody
product name :
TLR4, Human, mAb HTA125, R-PE
catalog :
HM2068PE-25
quantity :
25 tests
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HTA125
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
Hycult Biotech product webpage
citations: 21
Reference
Nativel B, Marimoutou M, Thon Hon V, Gunasekaran M, Andries J, Stanislas G, et al. Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue. PLoS ONE. 2013;8:e76039 pubmed publisher
Gaudreault E, Paquet Bouchard C, Fiola S, Le Bel M, Lacerte P, Shio M, et al. TAK1 contributes to the enhanced responsiveness of LTB(4)-treated neutrophils to Toll-like receptor ligands. Int Immunol. 2012;24:693-704 pubmed publisher
Satta N, Kruithof E, Fickentscher C, Dunoyer Geindre S, Boehlen F, Reber G, et al. Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies. Blood. 2011;117:5523-31 pubmed publisher
de Mast Q, de Groot P, van Heerde W, Roestenberg M, van Velzen J, Verbruggen B, et al. Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Br J Haematol. 2010;151:495-503 pubmed publisher
Brüll F, Mensink R, van den Hurk K, Duijvestijn A, Plat J. TLR2 activation is essential to induce a Th1 shift in human peripheral blood mononuclear cells by plant stanols and plant sterols. J Biol Chem. 2010;285:2951-8 pubmed publisher
Srinoulprasert Y, Pongtanalert P, Chawengkirttikul R, Chaiyaroj S. Engagement of Penicillium marneffei conidia with multiple pattern recognition receptors on human monocytes. Microbiol Immunol. 2009;53:162-72 pubmed publisher
Regueiro V, Moranta D, Campos M, Margareto J, Garmendia J, Bengoechea J. Klebsiella pneumoniae increases the levels of Toll-like receptors 2 and 4 in human airway epithelial cells. Infect Immun. 2009;77:714-24 pubmed publisher
Yamawaki H, Hirohata S, Miyoshi T, Takahashi K, Ogawa H, Shinohata R, et al. Hyaluronan receptors involved in cytokine induction in monocytes. Glycobiology. 2009;19:83-92 pubmed publisher
Parker L, Prestwich E, Ward J, Smythe E, Berry A, Triantafilou M, et al. A phosphatidylserine species inhibits a range of TLR- but not IL-1beta-induced inflammatory responses by disruption of membrane microdomains. J Immunol. 2008;181:5606-17 pubmed
Khan K, Kitajima M, Imamura T, Hiraki K, Fujishita A, Sekine I, et al. Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70. Hum Reprod. 2008;23:2210-9 pubmed publisher
Bas S, Neff L, Vuillet M, Spenato U, Seya T, Matsumoto M, et al. The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14. J Immunol. 2008;180:1158-68 pubmed
Triantafilou M, Uddin A, Maher S, Charalambous N, Hamm T, Alsumaiti A, et al. Anthrax toxin evades Toll-like receptor recognition, whereas its cell wall components trigger activation via TLR2/6 heterodimers. Cell Microbiol. 2007;9:2880-92 pubmed
Triantafilou M, Gamper F, Lepper P, Mouratis M, Schumann C, Harokopakis E, et al. Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells. Cell Microbiol. 2007;9:2030-9 pubmed
Mitsunari M, Yoshida S, Shoji T, Tsukihara S, Iwabe T, Harada T, et al. Macrophage-activating lipopeptide-2 induces cyclooxygenase-2 and prostaglandin E(2) via toll-like receptor 2 in human placental trophoblast cells. J Reprod Immunol. 2006;72:46-59 pubmed
Regueiro V, Campos M, Pons J, Alberti S, Bengoechea J. The uptake of a Klebsiella pneumoniae capsule polysaccharide mutant triggers an inflammatory response by human airway epithelial cells. Microbiology. 2006;152:555-66 pubmed
Van der Graaf C, Netea M, Verschueren I, Van der Meer J, Kullberg B. Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae. Infect Immun. 2005;73:7458-64 pubmed
Triantafilou K, Orthopoulos G, Vakakis E, Ahmed M, Golenbock D, Lepper P, et al. Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent. Cell Microbiol. 2005;7:1117-26 pubmed
Methe H, Kim J, Kofler S, Weis M, Nabauer M, Koglin J. Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Circulation. 2005;111:2654-61 pubmed
Methe H, Kim J, Kofler S, Nabauer M, Weis M. Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes. Arterioscler Thromb Vasc Biol. 2005;25:1439-45 pubmed
Lepper P, Triantafilou M, Schumann C, Schneider E, Triantafilou K. Lipopolysaccharides from Helicobacter pylori can act as antagonists for Toll-like receptor 4. Cell Microbiol. 2005;7:519-28 pubmed
Tsuneyoshi N, Fukudome K, Kohara J, Tomimasu R, Gauchat J, Nakatake H, et al. The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1. J Immunol. 2005;174:340-4 pubmed
product information
Catalog no :
HM2068PE-25
Title :
TLR4, Human, mAb HTA125, R-PE
Clone no :
HTA125
Quantity :
25 tests
Application code :
flow cytometry,functional studies,immunoassays,immunoprecipitation,western blot,immunofluorescence
Species :
human
Cross reactivity :
canine, cynomologus monkey, marmoset monkey, rhesus monkey
Host species :
mouse
Isotype :
IgG2a
Conjugate :
RP-E
Aliases :
CD284, Toll-like receptor 5
Type :
mAb
Antigen :
TLR4
Meta data :
CD284, Toll-like receptor 4
more info or order :
Hycult Biotech product webpage
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.