product summary
company name :
Hycult Biotech
product type :
antibody
product name :
BPI, Human, mAb 4H5
catalog :
HM2042
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4H5

The same clone is also sold as:
reactivity :
human
more info or order :
Hycult Biotech product webpage
citations: 22
Reference
Sandahl T, Kelsen J, Dige A, Dahlerup J, Agnholt J, Hvas C, et al. The lectin pathway of the complement system is downregulated in Crohn's disease patients who respond to anti-TNF-α therapy. J Crohns Colitis. 2014;8:521-8 pubmed publisher
Krarup A, Sørensen U, Matsushita M, Jensenius J, Thiel S. Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin. Infect Immun. 2005;73:1052-60 pubmed
Lacroix M, Dumestre-Pérard C, Schoehn G, Houen G, Cesbron J, Arlaud G, et al. Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin. J Immunol. 2009;182:456-65 pubmed
Schlapbach L, Kessler U, Thiel S, Hansen A, Nelle M, Ammann R, et al. M-ficolin in the neonatal period: Associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitis. Mol Immunol. 2009;46:2597-603 pubmed publisher
Schlapbach L, Aebi C, Hansen A, Hirt A, Jensenius J, Ammann R. H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients. Clin Exp Immunol. 2009;157:83-9 pubmed publisher
Reichhardt M, Loimaranta V, Thiel S, Finne J, Meri S, Jarva H. The salivary scavenger and agglutinin binds MBL and regulates the lectin pathway of complement in solution and on surfaces. Front Immunol. 2012;3:205 pubmed
Brinkmann C, Jensen L, Dagnæs-Hansen F, Holm I, Endo Y, Fujita T, et al. Mitochondria and the lectin pathway of complement. J Biol Chem. 2013;288:8016-27 pubmed publisher
Aichele D, Schnare M, Saake M, Rollinghoff M, Gessner A. Expression and antimicrobial function of bactericidal permeability-increasing protein in cystic fibrosis patients. Infect Immun. 2006;74:4708-14 pubmed
Honore C, Hummelshoj T, Hansen B, Madsen H, Eggleton P, Garred P. The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. Arthritis Rheum. 2007;56:1598-607 pubmed
Zacho R, Jensen L, Terp R, Jensenius J, Thiel S. Studies of the pattern recognition molecule H-ficolin: specificity and purification. J Biol Chem. 2012;287:8071-81 pubmed publisher
Michalski M, Szala A, St Swierzko A, Lukasiewicz J, Maciejewska A, Kilpatrick D, et al. H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates. Immunobiology. 2012;217:730-7 pubmed publisher
Wang C, Yim K, Poon T, Choy K, Chu C, Lui W, et al. Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia. Clin Chem. 2007;53:42-52 pubmed
Nathe K, Parad R, Van Marter L, Lund C, Suter E, Hernandez-Diaz S, et al. Endotoxin-directed innate immunity in tracheal aspirates of mechanically ventilated human neonates. Pediatr Res. 2009;66:191-6 pubmed publisher
Matsushita M, Kilpatrick D, Shiraki H, Liu Y, Tateishi K, Tsujimura M, et al. Purification, measurement of concentration, and functional complement assay of human ficolins. Methods Mol Biol. 2014;1100:141-59 pubmed publisher
Schaffer T, Flogerzi B, Schoepfer A, Seibold F, Muller S. Increased titers of anti-Saccharomyces cerevisiae antibodies in Crohn's disease patients with reduced H-ficolin levels but normal MASP-2 activity. J Crohns Colitis. 2013;7:e1-10 pubmed publisher
Fust G, Munthe-Fog L, Illes Z, Széplaki G, Molnar T, Pusch G, et al. Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke. J Neuroinflammation. 2011;8:185 pubmed publisher
Ameye L, Paesmans M, Thiel S, Jensenius J, Aoun M. M-ficolin levels are associated with the occurrence of severe infections in patients with haematological cancer undergoing chemotherapy. Clin Exp Immunol. 2012;167:303-8 pubmed publisher
Degn S, Hansen A, Steffensen R, Jacobsen C, Jensenius J, Thiel S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J Immunol. 2009;183:7371-8 pubmed publisher
Schlapbach L, Mattmann M, Thiel S, Boillat C, Otth M, Nelle M, et al. Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis. Clin Infect Dis. 2010;51:153-62 pubmed publisher
Terai I, Kobayashi K, Vaerman J, Mafune N. Degalactosylated and/or denatured IgA, but not native IgA in any form, bind to mannose-binding lectin. J Immunol. 2006;177:1737-45 pubmed
Hamad I, Christy Hunter A, Rutt K, Liu Z, Dai H, Moein Moghimi S. Complement activation by PEGylated single-walled carbon nanotubes is independent of C1q and alternative pathway turnover. Mol Immunol. 2008;45:3797-803 pubmed publisher
Imai N, Nishi S, Alchi B, Ueno M, Fukase S, Arakawa M, et al. Immunohistochemical evidence of activated lectin pathway in kidney allografts with peritubular capillary C4d deposition. Nephrol Dial Transplant. 2006;21:2589-95 pubmed
product information
Catalog no :
HM2042
Title :
BPI, Human, mAb 4H5
Clone no :
4H5
Quantity :
100 µg
Application code :
immunoassays
Species :
human
Host species :
mouse
Isotype :
IgG1
Conjugate :
purified
Aliases :
CAP57
Type :
mAb
Antigen :
BPI
Meta data :
CAP57
more info or order :
Hycult Biotech product webpage
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.