product summary
company name :
Hycult Biotech
product type :
antibody
product name :
C3b/iC3b/C3c, Mouse, mAb 2/11
catalog :
HM1065
quantity :
100 µg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
2/11
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 12
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 3b
Wu M, Rowe J, Fleming S. Complement Initiation Varies by Sex in Intestinal Ischemia Reperfusion Injury. Front Immunol. 2021;12:649882 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 4a
Han X, Zha H, Yang F, Guo B, Zhu B. Tumor-Derived Tissue Factor Aberrantly Activates Complement and Facilitates Lung Tumor Progression via Recruitment of Myeloid-Derived Suppressor Cells. Int J Mol Sci. 2017;18: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; fig s4b
Bulla R, Tripodo C, Rami D, Ling G, Agostinis C, Guarnotta C, et al. C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation. Nat Commun. 2016;7:10346 pubmed publisher
  • ELISA; human; loading ...; fig 1c
Bahia El Idrissi N, Hakobyan S, Ramaglia V, Geluk A, Morgan B, Das P, et al. Complement activation in leprosy: a retrospective study shows elevated circulating terminal complement complex in reactional leprosy. Clin Exp Immunol. 2016;184:338-46 pubmed publisher
  • ELISA; mouse; loading ...; fig 3
Penning M, Chua J, van Kooten C, Zandbergen M, Buurma A, Schutte J, et al. Classical Complement Pathway Activation in the Kidneys of Women With Preeclampsia. Hypertension. 2015;66:117-25 pubmed publisher
Lenis T, Sarfare S, Jiang Z, Lloyd M, Bok D, Radu R. Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease. Proc Natl Acad Sci U S A. 2017;114:3987-3992 pubmed publisher
Michailidou I, Naessens D, Hametner S, Guldenaar W, Kooi E, Geurts J, et al. Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis. Glia. 2017;65:264-277 pubmed publisher
Qiao Q, Teng X, Wang N, Lu R, Guo L, Zhang X, et al. A novel CRIg-targeted complement inhibitor protects cells from complement damage. FASEB J. 2014;28:4986-99 pubmed publisher
Catchpole I, Germaschewski V, Hoh Kam J, Lundh von Leithner P, Ford S, Gough G, et al. Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model. PLoS ONE. 2013;8:e65518 pubmed publisher
Hillian A, McMullen M, Sebastian B, Roychowdhury S, Rowchowdhury S, Kashyap S, et al. Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis. J Biol Chem. 2013;288:22565-75 pubmed publisher
Iwaki D, Kanno K, Takahashi M, Endo Y, Matsushita M, Fujita T. The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway. J Immunol. 2011;187:3751-8 pubmed publisher
Markiewski M, DeAngelis R, Benencia F, Ricklin Lichtsteiner S, Koutoulaki A, Gerard C, et al. Modulation of the antitumor immune response by complement. Nat Immunol. 2008;9:1225-35 pubmed publisher
product information
Catalog no :
HM1065
Title :
C3b/iC3b/C3c, Mouse, mAb 2/11
Clone no :
2/11
Quantity :
100 µg
Application code :
frozen sections,flow cytometry,functional studies,immunoassays,western blot,immunofluorescence
Species :
mouse
Host species :
rat
Isotype :
IgG1
Conjugate :
purified
Type :
mAb
Antigen :
C3b/iC3b/C3c
Meta data :
C3
more info or order :
company information
Hycult Biotech
Frontstraat 2a
5405 PB UDEN
support@hycultbiotech.com
http://www.hycultbiotech.com
31 0 413 25 13 35
headquarters: Netherlands
Hycult Biotech develops, produces and markets antibodies, antibody based products and more specifically immunoassays for innate immunity and directly related fields, with an emphasis on complement, neutrophil proteins, TLR, scavenger receptors and acute phase proteins. Furthermore, we have a strong interest in progressing research in the area of inflammation and cell damage caused by pathogens or oxidation factors.

Hycult Biotech’s mission and strategy is to advance insight in innate immunity related diseases, for the benefit of individuals and their quality of life.

As a leader within focused fields of immunology and cell biology, we develop products for the life sciences and in accordance with our mission it is our ambition to facilitate the transition of these products from research use into diagnostic testing. Many of our reagents are developed in close cooperation with scientists worldwide. Hycult Biotech has built a strong network with over 40 close scientific collaborations with leading international research institutes. We contribute to numerous projects and as a result, can continuously offer early access to an expanding range of innovative reagents. Hycult Biotech has been ISO-9001 certified since 1998 and we upgraded our certification to ISO-13485 in 2007, with a milestone of our first release of CE marked assays in 2009. Our vision, knowledgeable team and quality management system guarantee products of the highest grade combined with excellent technical service.