ADSL antibody [2D10] | GeneTex GTX84956 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

ADSL antibody [2D10]

catalog :

GTX84956

quantity :

100.00μl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2D10

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, FACS, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 2	Ben Sahra I, Hoxhaj G, Ricoult S, Asara J, Manning B. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. 2016;351:728-733 pubmed publisher

product information

Catalog No :

GTX84956

Product Name :

ADSL antibody [2D10]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

Clone :

2D10

Isotype :

IgG1

Product Description :

Mouse monoclonal antibody [2D10] to ADSL

CrossReactivity :

Hu, Dog, Mk, Rat

Background :

Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Immunogen :

Full length human recombinant protein of human ADSL (NP_000017) produced in HEK293T cell.

Specificity :

GTX84956 is specific for human ADSL (NP_000017).

Buffer :

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Uses :

FACS, IHC, IHC-P, WB

General References :

For short-term storage, store at 4°C or aliquot into working amounts and store at -20°C. For long-term storage, store at -70°C (aliquotted). Avoid repeated freeze-thaw cycles.

Image Legend_4 :

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-ADSL mouse monoclonal antibody. (GTX84956)

Image Legend_5 :

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-ADSL mouse monoclonal antibody. (GTX84956)

Image Legend_6 :

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-ADSL mouse monoclonal antibody. (GTX84956)

Image Legend_7 :

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-ADSL mouse monoclonal antibody. (GTX84956)

Image Legend_8 :

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-ADSL mouse monoclonal antibody. (GTX84956)

Image Legend_9 :

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-ADSL mouse monoclonal antibody. (GTX84956)

Image Legend_10 :

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-ADSL monoclonal antibody.

Image Legend_11 :

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ADSL (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-ADSL.

Image Legend_12 :

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-ADSL mouse monoclonal antibody. (GTX84956)