H2AX (phospho Ser140) antibody [3F2] | GeneTex GTX80694 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

H2AX (phospho Ser140) antibody [3F2]

catalog :

GTX80694

quantity :

100.00μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

3F2

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, FACS, immunohistochemistry - paraffin section

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:750	Lee J, Guo Z, Myler L, Zheng S, Paull T. Direct activation of ATM by resveratrol under oxidizing conditions. PLoS ONE. 2014;9:e97969 pubmed publisher
	Fox J, Sakamuru S, Huang R, Teneva N, Simmons S, Xia M, et al. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc Natl Acad Sci U S A. 2012;109:5423-8 pubmed publisher
	Kinjo T, Ham Terhune J, Peloponese J, Jeang K. Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker. J Virol. 2010;84:5431-7 pubmed publisher

product information

Catalog No :

GTX80694

Product Name :

H2AX (phospho Ser140) antibody [3F2]

Host Species :

Mouse

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

100.00μg

list of Pubmed id :

20219913,22431602,24933654

Clone :

3F2

Isotype :

IgG1

Product Description :

Mouse monoclonal antibody [3F2] to Ser140-phosphorylated H2AX

CrossReactivity :

Hu, Ms, Bov

Background :

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Jul 2008]

Immunogen :

Synthetic peptide sequence surrounding phosphorylated Ser140

Buffer :

PBS containing 0.05 % sodium azide and 1 mg/ml BSA

Uses :

ELISA, FACS, ICC/IF, IHC-P, WB

Concentration :

1mg/ml

General References :

-20° C, Avoid Freeze/Thaw Cycles