This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
beta Catenin antibody [EM-22]
catalog :
GTX80159
quantity :
100.00μg
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
EM-22
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation, FACS
product information
Catalog No :
GTX80159
Product Name :
beta Catenin antibody [EM-22]
Host Species :
Mouse
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
100.00μg
List Price :
299 USD
Clone :
EM-22
Isotype :
IgG1
Product Description :
Mouse Monoclonal antibody [EM-22] to beta Catenin
CrossReactivity :
Hu, Ms, Hm
Background :
Beta-catenin is a multifunctional protein involved both in cell adhesion and in activation of transcription. Calcium-dependent intercellular adhesion transmembrane glycoprotein E-cadherin interacts by its cytoplasmic domain with reciprocally bound alpha, beta and gamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton. Functional cadherin-catenin system is important for invasiveness of tumour cells. Beta-catenin level in cytoplasm is controlled by glycogen synthase kinase-3 beta. When activity of this kinase is blocked (e.g. by excessive stimulation of Wnt signaling pathway), hypophosphorylated stable form of beta-catenin accumulates in the cytoplasm, translocates to the nucleus and activates transcription of genes including those that are involved in cell cycle control. As a result, cell division and neoplastic transformation are promoted.Entrez Gene: 3p21
Immunogen :
Recombinant human beta-catenin
Specificity :
The antibody EM-22 reacts with C-terminal part of beta-catenin, an 88 kDa multifunctional protein involved both in cell adhesion and in activation of transcription.
Buffer :
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Uses :
FACS, ICC/IF, IP, WB
General References :
Store at 2-8°C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
company information
GeneTex
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