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product summary
company name :
GeneTex
product type :
antibody
product name :
CD25 antibody [MEM-181] (PE)
catalog :
GTX79988
quantity :
100.00 test
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
MEM-181
reactivity :
human
product information
Catalog No :
GTX79988
Product Name :
CD25 antibody [MEM-181] (PE)
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
PE
Product Type :
Primary antibody
Size :
100.00 test
List Price :
299 USD
Clone :
MEM-181
Isotype :
IgG1
Product Description :
PE-conjugated Mouse Monoclonal antibody [MEM-181] to CD25
CrossReactivity :
Hu
Background :
CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas. Entrez Gene: 10p15-p14
Immunogen :
PHA-activated peripheral blood leucocytes
Specificity :
The antibody MEM-181 reacts with CD25 (Interleukin-2 receptor alpha chain), a 55 kDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes, activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells); it is lost on resting B and T lymphocytes. HLDA VI; WS Code NL N-L024
Buffer :
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Uses :
FACS
General References :
Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is sto
company information
GeneTex
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