This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
p53 (phospho Ser20) antibody
catalog :
GTX78985
quantity :
100.00μg
price :
299 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section
product information
Catalog No :
GTX78985
Product Name :
p53 (phospho Ser20) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen Modification :
Phosphorylated
Product Type :
Primary antibody
Size :
100.00μg
List Price :
299 USD
Isotype :
IgG
Product Description :
Rabbit polyclonal antibody to P53 (phospho S20)
CrossReactivity :
Hu, Ms, Mk
Background :
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it s believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq]
Buffer :
PBS (without Mg2+and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol.
Uses :
ELISA, IHC, IHC-P, WB
Concentration :
1mg/ml
General References :
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
company information
GeneTex
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