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product summary
company name :
GeneTex
product type :
antibody
product name :
CD8 antibody [MEM-31] (PE)
catalog :
GTX78259
quantity :
100.00 test
price :
289 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
MEM-31
reactivity :
human
product information
Catalog No :
GTX78259
Product Name :
CD8 antibody [MEM-31] (PE)
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
PE
Product Type :
Primary antibody
Size :
100.00 test
List Price :
289 USD
Clone :
MEM-31
Isotype :
IgG2a
Product Description :
Monoclonal Antibody to CD8 (Human) Phycoerythrin (PE) conjugated
CrossReactivity :
Hu
Background :
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Immunogen :
Crude thymus membrane fraction.
Specificity :
The antibody recognizes a conformationally-dependent epitope of CD8 antigen (does not react with formaldehyde-fixed cells; negative in Western Blotting application). The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified. Gene location: human chromosome 2p12, CD8A, CD8B1
Buffer :
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Uses :
FACS
General References :
Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. Keep protected from prolonged exposure to light.
company information
GeneTex
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