This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
TLR4 antibody [HTA125]
catalog :
GTX75742
quantity :
100.00μg
price :
239 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HTA125
reactivity :
human, mouse, dog
application :
western blot, immunocytochemistry, neutralization, immunoprecipitation, FACS
citations: 7
| Reference |
|---|
Tabeta K, Yamazaki K, Akashi S, Miyake K, Kumada H, Umemoto T, et al. Toll-like receptors confer responsiveness to lipopolysaccharide from Porphyromonas gingivalis in human gingival fibroblasts. Infect Immun. 2000;68:3731-5 pubmed
|
Uehara A, Sugawara S, Takada H. Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans. J Med Microbiol. 2002;51:626-34 pubmed
|
Flo T, Ryan L, Latz E, Takeuchi O, Monks B, Lien E, et al. Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. J Biol Chem. 2002;277:35489-95 pubmed
|
Henning L, Azad A, Parsa K, Crowther J, Tridandapani S, Schlesinger L. Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol. 2008;180:7847-58 pubmed
|
product information
Catalog No :
GTX75742
Product Name :
TLR4 antibody [HTA125]
Host Species :
Mouse
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
100.00μg
List Price :
239 USD
list of Pubmed id :
18223193,12089142,10816537,12171292,23239500,18523248,23127653
Clone :
HTA125
Isotype :
IgG2a
Product Description :
Mouse monoclonal antibody [HTA125] to TLR4
CrossReactivity :
Hu, Ms, Dog, Pig, Cat, Gpig, RMK
Background :
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Specificity :
This antibody recognizes the human Toll like receptor 4 (TLR4).
Buffer :
Phosphate buffered saline containing 0.09% Sodium Azide
Uses :
Blocking, FACS, ICC/IF, IP, WB
General References :
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Image Legend_4 :
Staining of U937 cells with Mouse anti Human TLR4:RPE (GTX11227)
Image Legend_5 :
Staining of human peripheral blood monocytes with Mouse anti Human TLR4 (GTX75737)
Image Legend_6 :
Staining of human peripheral blood monocytes with Mouse anti Human TLR4: FITC (GTX28378)
Image Legend_7 :
Staining of human peripheral blood monocytes with Mouse anti Human TLR4: Low Endotoxin (GTX75740)
Image Legend_8 :
Staining of U937 cells with Mouse anti Human TLR4:RPE (GTX11227)
company information
GeneTex
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