CDK4 antibody [DCS 31.2] | GeneTex GTX75694 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

CDK4 antibody [DCS 31.2]

catalog :

GTX75694

quantity :

100.00μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DCS-31.2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:50	Knösel T, Werner M, Jung A, Kirchner T, Dürr H. Dedifferentiated chondrosarcoma mimicking a giant cell tumor. Is this low grade dedifferentiated chondrosarcoma?. Pathol Res Pract. 2014;210:194-7 pubmed publisher

product information

Catalog No :

GTX75694

Product Name :

CDK4 antibody [DCS 31.2]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

Clone :

DCS-31.2

Isotype :

IgG1

Product Description :

Mouse monoclonal antibody [DCS-31.2] to CDK4

CrossReactivity :

Hu, Ms, Rat

Background :

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

Specificity :

This antibody recognizes cyclin dependent kinase 4 (CDK4). Clone DCS 31.2 does not cross react with other cdk's and does not co-precipitate the D type cyclins bound to cdk4.

Buffer :

Phosphate buffered saline containing 0.08% Sodium Azide

Uses :

IHC-Fr, IP, WB

General References :

Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.