Ku80 antibody | GeneTex GTX70485 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

Ku80 antibody

catalog :

GTX70485

quantity :

100.00μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1	Morales J, Richard P, Patidar P, Motea E, Dang T, Manley J, et al. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016;12:e1006107 pubmed publisher
	Lipner M, Peng X, Jin C, Xu Y, Gao Y, East M, et al. Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy. JCI Insight. 2020;5: pubmed publisher

product information

Catalog No :

GTX70485

Product Name :

Ku80 antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

100.00μg

list of Pubmed id :

19030229,20185829,19119425,25180793

Isotype :

IgG

Product Description :

Rabbit Polyclonal to Ku80

CrossReactivity :

Hu, Ms

Background :

Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.

Specificity :

Reacts with residues 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein. Sequence is 100% conserved between human, mouse rat and hamster.

Buffer :

PBS containing 0.02% sodium azide.

Uses :

ELISA, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.