XPC antibody [3.26] | GeneTex GTX70294 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

XPC antibody [3.26]

catalog :

GTX70294

quantity :

100.00μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3.26

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse	Laposa R, Huang E, Cleaver J. Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome mice. Proc Natl Acad Sci U S A. 2007;104:1389-94 pubmed
	Kim H, Dejsuphong D, Adelmant G, Ceccaldi R, Yang K, Marto J, et al. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Mol Cell. 2014;54:107-118 pubmed publisher
	Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman M, Croteau D, et al. The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair. Carcinogenesis. 2013;34:2218-30 pubmed publisher
	Demetriou S, Ona Vu K, Sullivan E, Dong T, Hsu S, Oh D. Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen. Int J Cancer. 2012;131:1818-27 pubmed publisher
	de Feraudy S, Ridd K, Richards L, Kwok P, Revet I, Oh D, et al. The DNA damage-binding protein XPC is a frequent target for inactivation in squamous cell carcinomas. Am J Pathol. 2010;177:555-62 pubmed publisher
	Acu I, Liu T, Suino Powell K, Mooney S, D Assoro A, Rowland N, et al. Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells. Cancer Res. 2010;70:3320-8 pubmed publisher
	Takedachi A, Saijo M, Tanaka K. DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA. Mol Cell Biol. 2010;30:2708-23 pubmed publisher
	Rezvani H, Mahfouf W, Ali N, Chemin C, Ged C, Kim A, et al. Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes. Nucleic Acids Res. 2010;38:797-809 pubmed publisher
	Yan T, Seo Y, Kinsella T. Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells. Clin Cancer Res. 2009;15:6912-20 pubmed publisher
	Klein U, Nigg E. SUMO-dependent regulation of centrin-2. J Cell Sci. 2009;122:3312-21 pubmed publisher
	Wang Y, Liu X, Matsuda A, Plunkett W. Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair. Cancer Res. 2008;68:3881-9 pubmed publisher
	Ferguson Yates B, Li H, Dong T, Hsiao J, Oh D. Impaired repair of cyclobutane pyrimidine dimers in human keratinocytes deficient in p53 and p63. Carcinogenesis. 2008;29:70-5 pubmed
	Ferguson B, Oh D. Proficient global nucleotide excision repair in human keratinocytes but not in fibroblasts deficient in p53. Cancer Res. 2005;65:8723-9 pubmed
	Adimoolam S, Ford J. p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc Natl Acad Sci U S A. 2002;99:12985-90 pubmed

product information

Catalog No :

GTX70294

Product Name :

XPC antibody [3.26]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

list of Pubmed id :

17229834,19934262,20616346,16204041,20368362,19861440,17984111,19706679,20388771,18483273,12242345,22261839,23715498,24657165

Clone :

3.26

Isotype :

IgG1

Product Description :

Mouse monoclonal antibody to human XPC protein

CrossReactivity :

Hu, Ms

Background :

Human XPC (Xeroderma pigmentosum group C) is a member of a family of proteins that has been shown to be involved in the repair of DNA via the nucleotide excision repair (NER) pathway. Specifically, XPC is believed to be a part of a heteromeric protein complex that is involved in the recognition of the DNA lesions during global genomic repair but not transcription-coupled repair.

Immunogen :

Recombinant XPC purified from E. coli

Buffer :

Phosphate-buffered saline, pH 7.2, containing no preservatives

Uses :

ICC/IF, IHC-P, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

Image Legend_4 :

Western blot image of human XPC from HeLa whole cell lysate detected using rabbit polyclonal (lanes 1 and 2, catalog numbers GTX70308 and GTX70309, respectively) or monoclonal (lane 3, catalog number GTX70294) antibodies.

Image Legend_5 :

Western blot analysis of human XPC protein using anti-XPC 3.26 monoclonal antibody (GTX70294) in Raji whole cell extract. Lane 1: 1:1,000 dilution. Lane 2: 1:500 dilution.