This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
MDM2 antibody [SMP14]
catalog :
GTX70278
quantity :
50.00μg
price :
239 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SMP14
reactivity :
human, mouse
application :
immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
product information
Catalog No :
GTX70278
Product Name :
MDM2 antibody [SMP14]
Host Species :
Mouse
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
50.00μg
List Price :
239 USD
Clone :
SMP14
Isotype :
IgG1
Product Description :
Mouse monoclonal antibody [SMP14] to MDM2
CrossReactivity :
Hu, Ms
Background :
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008]
Immunogen :
Synthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2
Specificity :
This antibody recognizes MDM2.
Buffer :
Phosphate buffered saline containing 0.09% Sodium Azide
Uses :
IHC-Fr, IHC-P, IP, IHC-R
General References :
Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
company information
GeneTex
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