CtIP antibody [19E8] | GeneTex GTX70264 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

CtIP antibody [19E8]

catalog :

GTX70264

quantity :

100.00μg

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

19E8

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, proximity ligation assay

more info or order :

GeneTex product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
proximity ligation assay; human; fig 4b	Baude A, Aaes T, Zhai B, Al-Nakouzi N, Oo H, Daugaard M, et al. Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination. Nucleic Acids Res. 2016;44:2214-26 pubmed publisher
western blot; human; fig 4	Ahrabi S, Sarkar S, Pfister S, Pirovano G, Higgins G, Porter A, et al. A role for human homologous recombination factors in suppressing microhomology-mediated end joining. Nucleic Acids Res. 2016;44:5743-57 pubmed publisher
	Gu B, Chen P. Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint. Cell Cycle. 2009;8:1409-20 pubmed
	Liao C, Tsai C, Chang W, Lee W, Wang J. RB·E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1. J Biol Chem. 2010;285:33134-43 pubmed publisher
	Wu M, Soler D, Abba M, Nunez M, Baer R, Hatzis C, et al. CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Mol Cancer Res. 2007;5:1285-95 pubmed publisher
	Liu F, Lee W. CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression. Mol Cell Biol. 2006;26:3124-34 pubmed

product information

Catalog No :

GTX70264

Product Name :

CtIP antibody [19E8]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

List Price :

299 USD

list of Pubmed id :

20713352,18171986,16581787,19342888

Clone :

19E8

Isotype :

IgG

Product Description :

Mouse monoclonal antibody to human CtIP

CrossReactivity :

Hu, Ms

Background :

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disruppted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

Immunogen :

Human CtIP

Buffer :

Phosphate-buffered saline, pH 7.4, containing no preservatives

Uses :

ICC/IF, IP, WB, ChIP assay

Concentration :

1.3mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

more info or order :

GeneTex product webpage