| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:1000; fig 3a
| Rasmussen R, Gajjar M, Jensen K, Hamerlik P. Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma. Mol Oncol. 2016;10:751-63 pubmed publisher |
- immunoprecipitation; human; fig 6
| Larsen D, Hari F, Clapperton J, Gwerder M, Gutsche K, Altmeyer M, et al. The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage. Nat Cell Biol. 2014;16:792-803 pubmed publisher |
| Lee J, Guo Z, Myler L, Zheng S, Paull T. Direct activation of ATM by resveratrol under oxidizing conditions. PLoS ONE. 2014;9:e97969 pubmed publisher |
- western blot; human; 1:2000
| O Sullivan R, Arnoult N, Lackner D, Oganesian L, Haggblom C, Corpet A, et al. Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1. Nat Struct Mol Biol. 2014;21:167-74 pubmed publisher |
- western blot; human; fig 1
| Sappino A, Buser R, Seguin Q, Fernet M, Lesne L, Gumy Pause F, et al. The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage. Oncogenesis. 2012;1:e7 pubmed publisher |
| Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang J, et al. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell. 2017;68:414-430.e8 pubmed publisher |
| Li Z, Li J, Kong Y, Yan S, Ahmad N, Liu X. Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response. Cancer Res. 2017;77:3169-3180 pubmed publisher |
| Henrich S, Usadel C, Werwein E, Burdova K, Janscak P, Ferrari S, et al. Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling. Sci Rep. 2017;7:41663 pubmed publisher |
| Fu K, Sun X, Wier E, Hodgson A, Liu Y, Sears C, et al. Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-?B activation. elife. 2016;5: pubmed publisher |
| Sohn S, Hearing P. The adenovirus E4-ORF3 protein functions as a SUMO E3 ligase for TIF-1? sumoylation and poly-SUMO chain elongation. Proc Natl Acad Sci U S A. 2016;113:6725-30 pubmed publisher |
| Sohn S, Bridges R, Hearing P. Proteomic analysis of ubiquitin-like posttranslational modifications induced by the adenovirus E4-ORF3 protein. J Virol. 2015;89:1744-55 pubmed publisher |
| Wei F, Ojo D, Lin X, Wong N, He L, Yan J, et al. BMI1 attenuates etoposide-induced G2/M checkpoints via reducing ATM activation. Oncogene. 2015;34:3063-75 pubmed publisher |
| Koppensteiner R, Samartzis E, Noske A, von Teichman A, Dedes I, Gwerder M, et al. Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro. PLoS ONE. 2014;9:e100041 pubmed publisher |
| Sanjiv K, Chen C, Kakadiya R, Tala S, Suman S, Wu M, et al. PI3K Inhibition Augments the Therapeutic Efficacy of a 3a-aza-Cyclopenta[α]indene Derivative in Lung Cancer Cells. Transl Oncol. 2014;7:256-266.e5 pubmed publisher |
| Ohara M, Funyu Y, Ebara S, Sakamoto Y, Seki R, Iijima K, et al. Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination. J Radiat Res. 2014;55:690-8 pubmed publisher |
| Lee J, Mand M, Deshpande R, Kinoshita E, Yang S, Wyman C, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013;288:12840-51 pubmed publisher |
| Salewsky B, Wessendorf P, Hirsch D, Krenzlin H, Digweed M. Nijmegen breakage syndrome: the clearance pathway for mutant nibrin protein is allele specific. Gene. 2013;519:217-21 pubmed publisher |
| Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, et al. Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment. Cell Cycle. 2012;11:3837-50 pubmed publisher |
| Moudry P, Lukas C, Macurek L, Neumann B, Hériché J, Pepperkok R, et al. Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1. Cell Death Differ. 2012;19:798-807 pubmed publisher |
| E X, Pickering M, Debatis M, Castillo J, Lagadinos A, Wang S, et al. An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS Pathog. 2011;7:e1001342 pubmed publisher |
| Elaković I, Djordjevic A, Adzic M, Djordjevic J, Radojcic M, Matić G. Gender-specific response of brain corticosteroid receptors to stress and fluoxetine. Brain Res. 2011;1384:61-8 pubmed publisher |
| Demogines A, East A, Lee J, Grossman S, Sabeti P, Paull T, et al. Ancient and recent adaptive evolution of primate non-homologous end joining genes. PLoS Genet. 2010;6:e1001169 pubmed publisher |
| Cha H, Lowe J, Li H, Lee J, Belova G, Bulavin D, et al. Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response. Cancer Res. 2010;70:4112-22 pubmed publisher |
| Mandriota S, Buser R, Lesne L, Stouder C, Favaudon V, Maechler P, et al. Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. J Biol Chem. 2010;285:13092-106 pubmed publisher |
| Lee J, Goodarzi A, Jeggo P, Paull T. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 2010;29:574-85 pubmed publisher |
| Adzic M, Djordjevic A, Demonacos C, Krstic Demonacos M, Radojcic M. The role of phosphorylated glucocorticoid receptor in mitochondrial functions and apoptotic signalling in brain tissue of stressed Wistar rats. Int J Biochem Cell Biol. 2009;41:2181-8 pubmed publisher |
| Lins S, Kim R, Krüger L, Chrzanowska K, Seemanova E, Digweed M. Clinical variability and expression of the NBN c.657del5 allele in Nijmegen Breakage Syndrome. Gene. 2009;447:12-7 pubmed publisher |
| Collaco R, Bevington J, Bhrigu V, Kalman Maltese V, Trempe J. Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways. Virology. 2009;392:24-33 pubmed publisher |
| Vago R, Leva V, Biamonti G, Montecucco A. DNA ligase I and Nbs1 proteins associate in a complex and colocalize at replication factories. Cell Cycle. 2009;8:2600-7 pubmed |
| Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, et al. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol Oncol. 2008;2:296-316 pubmed publisher |
| Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori A, Gerrits B, et al. MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Res. 2009;37:2645-57 pubmed publisher |
| Schroering A, Williams K. Rapid induction of chromatin-associated DNA mismatch repair proteins after MNNG treatment. DNA Repair (Amst). 2008;7:951-69 pubmed publisher |
| Spycher C, Miller E, Townsend K, Pavic L, Morrice N, Janscak P, et al. Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J Cell Biol. 2008;181:227-40 pubmed publisher |
| den Dulk B, van Eijk P, de Ruijter M, Brandsma J, Brouwer J. The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4. DNA Repair (Amst). 2008;7:858-68 pubmed publisher |
| Takemura H, Rao V, Sordet O, Furuta T, Miao Z, Meng L, et al. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem. 2006;281:30814-23 pubmed |
| Krüger L, Demuth I, Neitzel H, Varon R, Sperling K, Chrzanowska K, et al. Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein. Carcinogenesis. 2007;28:107-11 pubmed |
| Cerosaletti K, Concannon P. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm. J Biol Chem. 2004;279:38813-9 pubmed |
