NBS1 antibody [1C3] | GeneTex GTX70222 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

NBS1 antibody [1C3]

catalog :

GTX70222

quantity :

100.00μg

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C3

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

GeneTex product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig s1c	Petroni M, Sardina F, Heil C, SahÃºn Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed publisher
western blot; human; fig 5	Harten S, Oey H, Bourke L, Bharti V, Isbel L, Daxinger L, et al. The recently identified modifier of murine metastable epialleles, Rearranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers. BMC Biol. 2015;13:21 pubmed publisher
western blot; human	Anderson V, Walton M, Eve P, Boxall K, Antoni L, Caldwell J, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011;71:463-72 pubmed publisher
	Ly P, Brunner S, Shoshani O, Kim D, Lan W, Pyntikova T, et al. Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nat Genet. 2019;51:705-715 pubmed publisher
	Hollingworth R, Horniblow R, Forrest C, Stewart G, Grand R. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2017;91: pubmed publisher
	Cesare A, Hayashi M, Crabbe L, Karlseder J. The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell. 2013;51:141-55 pubmed publisher
	Suzuki K, Yamauchi M, Yamashita S. ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome. Radiat Prot Dosimetry. 2011;143:279-83 pubmed publisher
	Chailleux C, Tyteca S, Papin C, Boudsocq F, Puget N, Courilleau C, et al. Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex. Biochem J. 2010;426:365-71 pubmed publisher
	Tseng S, Chang C, Wu K, Teng S. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. J Biol Chem. 2005;280:39594-600 pubmed
	Giannini G, Rinaldi C, Ristori E, Ambrosini M, Cerignoli F, Viel A, et al. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene. 2004;23:2640-7 pubmed
	Xu X, Stern D. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003;17:1842-8 pubmed

product information

Catalog No :

GTX70222

Product Name :

NBS1 antibody [1C3]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

List Price :

299 USD

list of Pubmed id :

20070254,15048091,21224259,21239475,16188882,14519663,23850488,25857663

Clone :

1C3

Isotype :

IgG1

Product Description :

Mouse monoclonal [1C3] NBS1

CrossReactivity :

Hu, Ms

Background :

Nijmegen breakage syndrome (NBS, nibrin) is an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The 1C3 antibody recognizes the 95 kDa NBS protein which contains a fork FHA head-associated domain that is adjacent to BRCT, a breast cancer C terminal domain, that has been implicated in protein-protein interactions. NBS is member of the Mre11/Rad50, p400 double-strand break repair complex involved in double-strand break repair and cell-cycle checkpoint functions.

Immunogen :

The complete coding region of the human p95/NBS1 expressed in E. coli.

Buffer :

Phosphate-buffered saline, pH 7.4, containing no preservatives

Uses :

ICC/IF, IP, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

more info or order :

GeneTex product webpage