p53 antibody [Pab240] | GeneTex GTX70218 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

p53 antibody [Pab240]

catalog :

GTX70218

quantity :

100.00μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PAb240

reactivity :

human, mouse, dogs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; dogs; loading ...; fig 4b	Tien Y, Chang M, Chu P, Lin C, Liu C, Liao A. Downregulation of the KLF4 transcription factor inhibits the proliferation and migration of canine mammary tumor cells. Vet J. 2015;205:244-53 pubmed publisher

product information

Catalog No :

GTX70218

Product Name :

p53 antibody [Pab240]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

list of Pubmed id :

25616642

Clone :

Pab240

Isotype :

IgG1

Product Description :

Mouse monoclonal antibody to human p53

CrossReactivity :

Hu, Ms, Dog

Background :

PAb240 specifically recognizes human p53 protein, a tumor suppressor gene that is mutated in a wide variety of sporadic and familial cancers. p53, a nuclear protein, mediates cell cycle arrest in response to DNA damage and therefore is important in the maintenance of genomic stability. Recent results indicate that an enhanced phosphorylation of p53 by ATM in response to DNA damage on SER15 is a mutation which reduces the ability of p53 to arrest cell growth.

Immunogen :

Gel-purified p53 containing p53 amino acids 14-389 (derived from the pSV53C p53 cDNA clone).

Buffer :

Phosphate-buffered saline, pH 7.4, containing no preservatives

Uses :

ELISA, FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.