p53 antibody [D01] | GeneTex GTX70214 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

p53 antibody [D01]

catalog :

GTX70214

quantity :

200.00μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D01

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, FACS, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; human	Lee J, Guo Z, Myler L, Zheng S, Paull T. Direct activation of ATM by resveratrol under oxidizing conditions. PLoS ONE. 2014;9:e97969 pubmed publisher
	Wang Y, Zhu S, Wei W, Tu Y, Chen C, Song J, et al. Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice. Aging (Albany NY). 2020;12:20184-20197 pubmed publisher
	Bensaad K, Tsuruta A, Selak M, Vidal M, Nakano K, Bartrons R, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell. 2006;126:107-20 pubmed
	Luo J, Nikolaev A, Imai S, Chen D, Su F, Shiloh A, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell. 2001;107:137-48 pubmed
	Marchenko N, Zaika A, Moll U. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem. 2000;275:16202-12 pubmed
	Vojtesek B, Fisher C, Barnes D, Lane D. Comparison between p53 staining in tissue sections and p53 proteins levels measured by an ELISA technique. Br J Cancer. 1993;67:1254-8 pubmed

product information

Catalog No :

GTX70214

Product Name :

p53 antibody [D01]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

200.00μg

list of Pubmed id :

24933654,11672522,16839880,7685617,10821866

Clone :

D01

Isotype :

IgG2a

Product Description :

Mouse monoclonal antibody to human p53

CrossReactivity :

Background :

The p53 antibody, clone DO1, specifically recognizes an epitope at the N-terminal end of the human p53 protein between amino acids 20-25. p53 is a tumor suppressor gene that is mutated in a wide variety of sporadic and familial cancers. And p53, as a nuclear protein, mediates cell cycle arrest in response to DNA damage and therefore is important in the maintenance of genomic stability. Recent results indicate an enhanced phosphorylation of p53 by ATM in response to DNA damage on SER15, a mutation which reduces the ability of p53 to arrest cell growth.

Immunogen :

Recombinant human p53 expressed in E. coli.

Buffer :

PBS

Uses :

ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB, ChIP/Chip

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.