Jab1 antibody [8H8.5] | GeneTex GTX70207 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

Jab1 antibody [8H8.5]

catalog :

GTX70207

quantity :

100.00μl

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8H8.5

The same clone is also sold as:

Invitrogen: MA1-23248
Abnova: MAB12626
LifeSpan Biosciences: LS-B4786

reactivity :

human, mouse

application :

western blot, immunoprecipitation

more info or order :

GeneTex product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse immunoprecipitation; human western blot; human	Chen J, Shin J, Zhao R, Phan L, Wang H, Xue Y, et al. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014;5:5384 pubmed publisher
	Mitsuhashi T, Yonemoto J, Sone H, Kosuge Y, Kosaki K, Takahashi T. In utero exposure to dioxin causes neocortical dysgenesis through the actions of p27Kip1. Proc Natl Acad Sci U S A. 2010;107:16331-5 pubmed publisher
	Doronkin S, Djagaeva I, Beckendorf S. The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis. Dev Cell. 2003;4:699-710 pubmed
	Burger-Kentischer A, Finkelmeier D, Thiele M, Schmucker J, Geiger G, Tovar G, et al. Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif. FEBS Lett. 2005;579:1693-701 pubmed
	Feist M, Huang X, Muller J, Rau B, Dubiel W. Can hyperthermic intraperitoneal chemotherapy efficiency be improved by blocking the DNA repair factor COP9 signalosome?. Int J Colorectal Dis. 2014;29:673-80 pubmed publisher
	da Silva Correia J, Miranda Y, Leonard N, Ulevitch R. The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis. J Biol Chem. 2007;282:12557-65 pubmed

image

image 1 :

Customer Review using GTX70207 - D10 T cells were lysed in IP buffer (20mM Tris-HCl, pH 7.5, 50mM NaCl, 50mM NaF, 10mM -glycerophosphate, 1% Triton X-100, 1mM PMSF).

image 2 :

Part of a customer review using GTX70207

image 3 :

Detection of human Jab1 protein in HeLa whole cell lysate using GeneTex monoclonal antibody GTX70207

product information

Catalog No :

GTX70207

Product Name :

Jab1 antibody [8H8.5]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

299 USD

list of Pubmed id :

15757663,12737805,17337451,20805476,24728517,25395170

Clone :

8H8.5

Isotype :

IgG2a

Product Description :

Mouse monoclonal antibody to human Jab1

CrossReactivity :

Hu, Ms, Dm

Background :

JAB-1 is a 38a protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

Immunogen :

The full-length mouse JAB-1 gene expressed in E. coli.

Buffer :

Phosphate-buffered saline, pH 7.4, containing no preservatives

Uses :

IP, WB

Concentration :

Lot Dependent: 0.77-1

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

more info or order :

GeneTex product webpage