Jab1 antibody [2A10.8] | GeneTex GTX70203 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

Jab1 antibody [2A10.8]

catalog :

GTX70203

quantity :

100.00μg

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2A10

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 7

Reference
Jumpertz S, Hennes T, Asare Y, Vervoorts J, Bernhagen J, Schütz A. The β-catenin E3 ubiquitin ligase SIAH-1 is regulated by CSN5/JAB1 in CRC cells. Cell Signal. 2014;26:2051-9 pubmed publisher
Gemmill R, Bemis L, Lee J, Sozen M, Baron A, Zeng C, et al. The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene. 2002;21:3507-16 pubmed
Yun J, Tomida A, Andoh T, Tsuruo T. Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5. J Biol Chem. 2004;279:31296-303 pubmed
Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, et al. The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A. 2011;108:E577-85 pubmed publisher
McCall C, Miliani de Marval P, Chastain P, Jackson S, He Y, Kotake Y, et al. Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol. 2008;28:5621-33 pubmed publisher
Doronkin S, Djagaeva I, Beckendorf S. CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint. Development. 2002;129:5053-64 pubmed
Korbonits M, Chahal H, Kaltsas G, Jordan S, Urmanova Y, Khalimova Z, et al. Expression of phosphorylated p27(Kip1) protein and Jun activation domain-binding protein 1 in human pituitary tumors. J Clin Endocrinol Metab. 2002;87:2635-43 pubmed

product information

Catalog No :

GTX70203

Product Name :

Jab1 antibody [2A10.8]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

List Price :

299 USD

list of Pubmed id :

12397113,12050228,21817065,12032852,15126503,18606781,24882689

Clone :

2A10

Isotype :

IgG2b

Product Description :

Mouse monoclonal antibody to human Jab1

CrossReactivity :

Hu, Ms, Dm, Rat

Background :

JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.

Immunogen :

The full-length mouse JAB-1 gene expressed in E. coli.

Buffer :

Phosphate-buffered saline, pH 7.4, containing no preservatives

Uses :

ICC/IF, IHC, IP, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

Image Legend_4 :

Sample (50 ug of whole cell lysate) A: mouse brain 10% SDS PAGE GTX70203 diluted at 1:10000