DNA ligase I antibody [10H5] | GeneTex GTX70141 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

DNA ligase I antibody [10H5]

catalog :

GTX70141

quantity :

100.00μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10H5

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig s2	Masaoka A, Gassman N, Horton J, Kedar P, Witt K, Hobbs C, et al. Interaction between DNA Polymerase ? and BRCA1. PLoS ONE. 2013;8:e66801 pubmed publisher
	Horton J, Stefanick D, Gassman N, Williams J, Gabel S, Cuneo M, et al. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA Repair (Amst). 2013;12:774-85 pubmed publisher
	Prasad R, Williams J, Hou E, Wilson S. Pol ? associated complex and base excision repair factors in mouse fibroblasts. Nucleic Acids Res. 2012;40:11571-82 pubmed publisher
	Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton J, et al. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA Repair (Amst). 2010;9:109-19 pubmed publisher
	Guo Z, Zheng L, Dai H, Zhou M, Xu H, Shen B. Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity. Nucleic Acids Res. 2009;37:3431-41 pubmed publisher
	Song W, Levin D, Varkey J, Post S, Bermudez V, Hurwitz J, et al. A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. J Biol Chem. 2007;282:22721-30 pubmed
	Windhofer F, Wu W, Iliakis G. Low levels of DNA ligases III and IV sufficient for effective NHEJ. J Cell Physiol. 2007;213:475-83 pubmed
	Wang W, Lindsey Boltz L, Sancar A, Bambara R. Mechanism of stimulation of human DNA ligase I by the Rad9-rad1-Hus1 checkpoint complex. J Biol Chem. 2006;281:20865-72 pubmed
	Wang H, Rosidi B, Perrault R, Wang M, Zhang L, Windhofer F, et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res. 2005;65:4020-30 pubmed

product information

Catalog No :

GTX70141

Product Name :

DNA ligase I antibody [10H5]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

list of Pubmed id :

17561505,20006562,15899791,23042675,17492771,16731526,19336415,23826138,23871146

Clone :

10H5

Isotype :

IgG1

Product Description :

Mouse monoclonal [10H5] to DNA ligase I

CrossReactivity :

Hu, Ms

Background :

There are four distinct ligase proteins found in mammalian cells. The activity of these DNA ligases is required for the joining of DNA strand breaks that occur during DNA replication, repair and recombination. DNA ligase I migrates as a 125kDa phosphoprotein and is implicated in joining Okazaki fragments during DNA synthesis. It also has a role in the base and nucleotide excision repair pathways.

Immunogen :

Full-length recombinant human DNA Ligase I protein

Buffer :

Phosphate-buffered saline, pH 7.2, containing no preservatives

Uses :

IP, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.