ATM antibody [5C2] | GeneTex GTX70107 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

ATM antibody [5C2]

catalog :

GTX70107

quantity :

100.00μg

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5C2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

GeneTex product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; human	Chen J, Ozanne S. Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress. FEBS Lett. 2006;580:6669-73 pubmed
western blot; mouse; 1:500	Gapud E, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald G, et al. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A. 2011;108:2022-7 pubmed publisher
immunocytochemistry; human	Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol. 2008;82:9639-46 pubmed publisher
	Du F, Zhang M, Li X, Yang C, Meng H, Wang D, et al. Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Biochem Biophys Res Commun. 2014;452:1034-9 pubmed publisher
	Sun Y, Jiang X, Chen S, Price B. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006;580:4353-6 pubmed
	Vogel R, Seyffert M, Strasser R, de Oliveira A, Dresch C, Glauser D, et al. Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection. J Virol. 2012;86:143-55 pubmed publisher
	Gonzalez-Suarez I, Redwood A, Perkins S, Vermolen B, Lichtensztejin D, Grotsky D, et al. Novel roles for A-type lamins in telomere biology and the DNA damage response pathway. EMBO J. 2009;28:2414-27 pubmed publisher
	Cam H, Easton J, High A, Houghton P. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell. 2010;40:509-20 pubmed publisher
	Lai C, Jeng K, Machida K, Cheng Y, Lai M. Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation. Virology. 2008;370:295-309 pubmed
	Craig A, Holcakova J, Finlan L, Nekulova M, Hrstka R, Gueven N, et al. DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. Mol Cancer. 2010;9:195 pubmed publisher
	Rankin A, Sarkar S, Faller D. Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells. J Cell Physiol. 2012;227:2586-94 pubmed publisher
	Javvadi P, Makino H, Das A, Lin Y, Chen D, Chen B, et al. Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Mol Cancer Res. 2012;10:1359-68 pubmed publisher
	Siehler S, Schrauder M, Gerischer U, Cantor S, Marra G, Wiesmuller L. Human MutL-complexes monitor homologous recombination independently of mismatch repair. DNA Repair (Amst). 2009;8:242-52 pubmed publisher
	Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed

product information

Catalog No :

GTX70107

Product Name :

ATM antibody [5C2]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

List Price :

299 USD

list of Pubmed id :

19629036,16513843,21898405,22923485,16844118,20663147,21245316,21095582,17126333,22013059,19022408,17931678,25240135

Clone :

5C2

Isotype :

IgG1

Product Description :

Mouse monoclonal [5C2] to ATM

CrossReactivity :

Hu, Ms, Mk, Rat

Background :

ATM-5C2 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.

Immunogen :

Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.

Buffer :

Phosphate-buffered saline, pH7.4, containing no preservatives

Uses :

ICC/IF, IHC, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

more info or order :

GeneTex product webpage