ATM antibody [3E8] | GeneTex GTX70105 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

ATM antibody [3E8]

catalog :

GTX70105

quantity :

100.00μg

price :

299 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3E8

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation, immunohistochemistry - paraffin section

citations: 5

Reference
Post S, Weng Y, Cimprich K, Chen L, Xu Y, Lee E. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Proc Natl Acad Sci U S A. 2001;98:13102-7 pubmed
Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed
Chen M, Lin Y, Lieberman H, Chen G, Lee E. ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. J Biol Chem. 2001;276:16580-6 pubmed
Bai L, Kao J, Law D, Merchant J. Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. Gastroenterology. 2006;131:841-52 pubmed
Fini L, Hotchkiss E, Fogliano V, Graziani G, Romano M, De Vol E, et al. Chemopreventive properties of pinoresinol-rich olive oil involve a selective activation of the ATM-p53 cascade in colon cancer cell lines. Carcinogenesis. 2008;29:139-46 pubmed

product information

Catalog No :

GTX70105

Product Name :

ATM antibody [3E8]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

List Price :

299 USD

list of Pubmed id :

11687627,11278446,17999988,16513843,16952553

Clone :

3E8

Isotype :

IgG1

Product Description :

Mouse monoclonal [3E8] to ATM

CrossReactivity :

Hu, Ms, Mk, Rat

Background :

ATM-3E8 recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.

Immunogen :

Recombinant protein expressed in E. coli corresponding to amino acids 980-1512.

Buffer :

Phosphate-buffered saline, pH7.4, containing no preservatives

Uses :

IHC-P, IP, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

Image Legend_4 :

Immunohistochemical analysis of paraffin-embedded RT2 xenograft, using ATM(GTX70105) antibody at 1:200 dilution.

Image Legend_5 :

Immunohistochemical analysis of paraffin-embedded C2C12 xenograft, using ATM(GTX70105) antibody at 1:200 dilution.