product summary
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company name :
GeneTex
product type :
antibody
product name :
ATM antibody [2C1]
catalog :
GTX70103
quantity :
100.00μg
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2C1
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, FACS, immunohistochemistry - paraffin section
more info or order :
GeneTex product webpage
citations: 171
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 1f
Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed publisher
  • western blot; human; loading ...; fig s2e
Clarke T, Sanchez Bailon M, Chiang K, Reynolds J, Herrero Ruiz J, Bandeiras T, et al. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017;65:900-916.e7 pubmed publisher
  • western blot; mouse; fig 3
He D, Xiang J, Li B, Liu H. The dynamic behavior of Ect2 in response to DNA damage. Sci Rep. 2016;6:24504 pubmed publisher
  • immunoprecipitation; human; fig 4
Salzman D, Nakamura K, Nallur S, Dookwah M, Metheetrairut C, Slack F, et al. miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage. Nat Commun. 2016;7:10954 pubmed publisher
  • western blot; human; fig 5
Wang Y, Xu Q, Sack L, Kang C, Elledge S. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016;30:293-306 pubmed publisher
  • western blot; human; fig 1
Kuo C, Li X, Stark J, Shih H, Ann D. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle. 2016;15:787-98 pubmed publisher
  • immunocytochemistry; human; fig 2
  • western blot; human; fig 4
Chou W, Hu L, Hsiung C, Shen C. Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway. Carcinogenesis. 2015;36:832-40 pubmed publisher
  • western blot; human; fig 5
Nakajima N, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS ONE. 2015;10:e0122582 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5b
Kumari A, Owen N, Juarez E, McCullough A. BLM protein mitigates formaldehyde-induced genomic instability. DNA Repair (Amst). 2015;28:73-82 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Ruan X, Zuo Q, Jia H, Chau J, Lin J, Ao J, et al. P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers. J Mol Cell Biol. 2015;7:105-18 pubmed publisher
  • western blot; human; fig s5
Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid J, Herrador R, et al. Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells. J Cell Biol. 2015;208:563-79 pubmed publisher
  • immunohistochemistry; human; fig 1
Gibbs Seymour I, Markiewicz E, Bekker Jensen S, Mailand N, Hutchison C. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell. 2015;14:162-9 pubmed publisher
  • western blot; human; fig 6
Ray Chaudhuri A, Ahuja A, Herrador R, Lopes M. Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase. Mol Cell Biol. 2015;35:856-65 pubmed publisher
  • western blot; human; fig 3
Hühn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed publisher
  • western blot; human
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed publisher
  • western blot; human; fig s2
Shibata A, Moiani D, Arvai A, Perry J, Harding S, Genois M, et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014;53:7-18 pubmed publisher
  • western blot; mouse; 1:500
Hardee M, Marciscano A, Medina Ramirez C, Zagzag D, Narayana A, Lonning S, et al. Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-?. Cancer Res. 2012;72:4119-29 pubmed publisher
  • western blot; human
Guo Z, Deshpande R, Paull T. ATM activation in the presence of oxidative stress. Cell Cycle. 2010;9:4805-11 pubmed
  • western blot; human; fig 5
Sakasai R, Teraoka H, Takagi M, Tibbetts R. Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison. J Biol Chem. 2010;285:15201-8 pubmed publisher
  • western blot; human; fig 2
Sakasai R, Teraoka H, Tibbetts R. Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin. DNA Repair (Amst). 2010;9:76-82 pubmed publisher
  • immunoprecipitation; human
  • western blot; human
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, et al. The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication. J Virol. 2008;82:9639-46 pubmed publisher
  • western blot; mouse; 1:500
Yalcin S, Zhang X, Luciano J, Mungamuri S, Marinkovic D, Vercherat C, et al. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008;283:25692-705 pubmed publisher
  • western blot; human
Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008;283:13549-55 pubmed publisher
  • western blot; mouse; 1:1000
Pusapati R, Rounbehler R, Hong S, Powers J, Yan M, Kiguchi K, et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A. 2006;103:1446-51 pubmed
Yang Z, Shen Y, Oishi H, Matteson E, Tian L, Goronzy J, et al. Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis. Sci Transl Med. 2016;8:331ra38 pubmed publisher
Saquilabon Cruz G, Kong X, Silva B, Khatibzadeh N, Thai R, Berns M, et al. Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites. Nucleic Acids Res. 2016;44:e27 pubmed publisher
Zhang J, Tripathi D, Jing J, Alexander A, Kim J, Powell R, et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015;17:1259-1269 pubmed publisher
Sajish M, Schimmel P. A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature. 2015;519:370-3 pubmed publisher
Du F, Zhang M, Li X, Yang C, Meng H, Wang D, et al. Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Biochem Biophys Res Commun. 2014;452:1034-9 pubmed publisher
Kotov I, Siebring van Olst E, Knobel P, van der Meulen Muileman I, Felley Bosco E, van Beusechem V, et al. Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress. Mol Oncol. 2014;8:1747-59 pubmed publisher
Lee J, Guo Z, Myler L, Zheng S, Paull T. Direct activation of ATM by resveratrol under oxidizing conditions. PLoS ONE. 2014;9:e97969 pubmed publisher
Hennig J, McShane M, Cordes N, Eke I. APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM. Cell Death Dis. 2014;5:e1199 pubmed publisher
Wang C, Huang E, Huang S, Chung B. DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress. Oncogene. 2015;34:1263-9 pubmed publisher
Sharma N, Lebedeva M, Thomas T, Kovalenko O, Stumpf J, Shadel G, et al. Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia. DNA Repair (Amst). 2014;13:22-31 pubmed publisher
Lim H, Xie L, Zhang W, Li R, Chen Z, Wu G, et al. Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway. PLoS ONE. 2013;8:e74334 pubmed publisher
Bowen C, Ju J, Lee J, Paull T, Gelmann E. Functional activation of ATM by the prostate cancer suppressor NKX3.1. Cell Rep. 2013;4:516-29 pubmed publisher
Tripathi D, Chowdhury R, Trudel L, Tee A, Slack R, Walker C, et al. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A. 2013;110:E2950-7 pubmed publisher
Zhang X, Jia D, Liu H, Zhu N, Zhang W, Feng J, et al. Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential. PLoS ONE. 2013;8:e62527 pubmed publisher
Lee J, Mand M, Deshpande R, Kinoshita E, Yang S, Wyman C, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013;288:12840-51 pubmed publisher
Stewart R, Kozlov S, Matigian N, Wali G, Gatei M, Sutharsan R, et al. A patient-derived olfactory stem cell disease model for ataxia-telangiectasia. Hum Mol Genet. 2013;22:2495-509 pubmed publisher
Wu C, Dong Y, Liang Q, He X, Ng S, Chan F, et al. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. PLoS ONE. 2013;8:e57036 pubmed publisher
Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, et al. A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol. 2013;200:173-86 pubmed publisher
Choi S, Jang H, Roe J, Kim S, Cho E, Youn H. Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress. Nucleic Acids Res. 2013;41:2180-90 pubmed publisher
Shi Y, Felley Bosco E, Marti T, Orlowski K, Pruschy M, Stahel R. Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer. 2012;12:571 pubmed publisher
Nayler S, Gatei M, Kozlov S, Gatti R, Mar J, Wells C, et al. Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype. Stem Cells Transl Med. 2012;1:523-35 pubmed publisher
Murad N, Cullen J, McKenzie M, Ryan M, Thorburn D, Gueven N, et al. Mitochondrial dysfunction in a novel form of autosomal recessive ataxia. Mitochondrion. 2013;13:235-45 pubmed publisher
Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, et al. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells. 2012;17:962-70 pubmed publisher
Shi Y, Felley Bosco E, Marti T, Stahel R. Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. PLoS ONE. 2012;7:e45354 pubmed publisher
Baritaud M, Cabon L, Delavallée L, Galán Malo P, Gilles M, Brunelle Navas M, et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis. 2012;3:e390 pubmed publisher
Mahajan K, Coppola D, Rawal B, Chen Y, Lawrence H, Engelman R, et al. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012;287:22112-22 pubmed publisher
Hsu C, Lee Y, Yeh S, Chen C, Wu C, Wang T, et al. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. J Biol Chem. 2012;287:22533-48 pubmed publisher
Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, et al. ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis. Aging (Albany NY). 2012;4:290-304 pubmed
Ai L, Skehan R, Saydi J, Lin T, Brown K. Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor ? light chain enhancer of activated B cells (NF?B) signaling controls basal and DNA damage-induced transglutaminase 2 expression. J Biol Chem. 2012;287:18330-41 pubmed publisher
Zhang J, De Toledo S, Pandey B, Guo G, Pain D, Li H, et al. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc Natl Acad Sci U S A. 2012;109:E926-33 pubmed publisher
Kang M, So E, Ouchi T. Deregulation of DNA damage response pathway by intercellular contact. J Biol Chem. 2012;287:16246-55 pubmed publisher
Hao Z, Duncan G, Su Y, Li W, Silvester J, Hong C, et al. The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012;209:173-86 pubmed publisher
Xu Y, Parmar K, Du F, Price B, Sun Y. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol. 2011;2:295-302 pubmed
Assaily W, Rubinger D, Wheaton K, Lin Y, Ma W, Xuan W, et al. ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress. Mol Cell. 2011;44:491-501 pubmed publisher
Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M. Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation. J Biol Chem. 2011;286:39200-10 pubmed publisher
Brown J, Roberts T, Richards R, Woods R, Birrell G, Lim Y, et al. A novel role for hSMG-1 in stress granule formation. Mol Cell Biol. 2011;31:4417-29 pubmed publisher
Hada M, Huff J, Patel Z, Kawata T, Pluth J, George K, et al. AT cells are not radiosensitive for simple chromosomal exchanges at low dose. Mutat Res. 2011;716:76-83 pubmed publisher
Gatei M, Jakob B, Chen P, Kijas A, Becherel O, Gueven N, et al. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J Biol Chem. 2011;286:31542-56 pubmed publisher
Luo K, Yuan J, Lou Z. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem. 2011;286:28192-9 pubmed publisher
Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, et al. A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia. J Cell Sci. 2011;124:1943-51 pubmed publisher
Shouse G, Nobumori Y, Panowicz M, Liu X. ATM-mediated phosphorylation activates the tumor-suppressive function of B56?-PP2A. Oncogene. 2011;30:3755-65 pubmed publisher
Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, et al. The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination. Nucleic Acids Res. 2011;39:5459-73 pubmed publisher
Chen Y, Chen C, Riley D, Chen P. Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR. Cell Cycle. 2011;10:655-63 pubmed
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, et al. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair (Amst). 2011;10:314-21 pubmed publisher
Urquhart A, Gatei M, Richard D, Khanna K. ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr. 2011;2:1 pubmed publisher
Ruiz Z, Mihaylov I, Cotmore S, Tattersall P. Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM). Virology. 2011;410:375-84 pubmed publisher
Kozlov S, Graham M, Jakob B, Tobias F, Kijas A, Tanuji M, et al. Autophosphorylation and ATM activation: additional sites add to the complexity. J Biol Chem. 2011;286:9107-19 pubmed publisher
Powell M, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev S, et al. Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl. 2010;4:337-51 pubmed publisher
Xu Y, Sun Y, Jiang X, Ayrapetov M, Moskwa P, Yang S, et al. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol. 2010;191:31-43 pubmed publisher
Huang Q, Tomida S, Masuda Y, Arima C, Cao K, Kasahara T, et al. Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer. Cancer Res. 2010;70:8407-16 pubmed publisher
Shanware N, Zhan L, Hutchinson J, Kim S, Williams L, Tibbetts R. Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. PLoS ONE. 2010;5:e12173 pubmed publisher
Lee J, Choy M, Ngo L, Foster S, Marks P. Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair. Proc Natl Acad Sci U S A. 2010;107:14639-44 pubmed publisher
Fang Z, Kozlov S, McKay M, Woods R, Birrell G, Sprung C, et al. Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integr. 2010;1:9 pubmed publisher
Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, et al. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. Cell Cycle. 2010;9:2814-22 pubmed
Bowen C, Gelmann E. NKX3.1 activates cellular response to DNA damage. Cancer Res. 2010;70:3089-97 pubmed publisher
Kongruttanachok N, Phuangphairoj C, Thongnak A, Ponyeam W, Rattanatanyong P, Pornthanakasem W, et al. Replication independent DNA double-strand break retention may prevent genomic instability. Mol Cancer. 2010;9:70 pubmed publisher
Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010;24:549-60 pubmed publisher
Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y. Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences. Mol Cell Biol. 2010;30:1620-33 pubmed publisher
Hu H, Du L, Nagabayashi G, Seeger R, Gatti R. ATM is down-regulated by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010;107:1506-11 pubmed publisher
Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa Saito M, Kiyono T, et al. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J Cell Sci. 2010;123:225-35 pubmed publisher
So S, Davis A, Chen D. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol. 2009;187:977-90 pubmed publisher
Bolderson E, Tomimatsu N, Richard D, Boucher D, Kumar R, Pandita T, et al. Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 2010;38:1821-31 pubmed publisher
Britton S, Frit P, Biard D, Salles B, Calsou P. ARTEMIS nuclease facilitates apoptotic chromatin cleavage. Cancer Res. 2009;69:8120-6 pubmed publisher
Papp L, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, et al. SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress. Antioxid Redox Signal. 2010;12:797-808 pubmed publisher
Sun Y, Jiang X, Xu Y, Ayrapetov M, Moreau L, Whetstine J, et al. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009;11:1376-82 pubmed publisher
Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa Saito M, Waga S, et al. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J Cell Sci. 2009;122:1184-91 pubmed publisher
Cui B, Johnson S, Bullock N, Ali Osman F, Bigner D, Friedman H. Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Mol Pharmacol. 2009;75:1356-63 pubmed publisher
Heffernan T, Kawasumi M, Blasina A, Anderes K, Conney A, Nghiem P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol. 2009;129:1805-15 pubmed publisher
Nahas S, Butch A, Du L, Gatti R. Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes. Clin Chem. 2009;55:463-72 pubmed publisher
Chou W, Wang H, Wong F, Ding S, Wu P, Shieh S, et al. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 2008;27:3140-50 pubmed publisher
Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat P, et al. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol. 2009;83:117-27 pubmed publisher
Meulle A, Salles B, Daviaud D, Valet P, Muller C. Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis. PLoS ONE. 2008;3:e3345 pubmed publisher
Martin L, Liu Z, Pipino J, Chestnut B, Landek M. Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cereb Cortex. 2009;19:1273-93 pubmed publisher
Stohr B, Blackburn E. ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells. Cancer Res. 2008;68:5309-17 pubmed publisher
Luo H, Li Y, Mu J, Zhang J, Tonaka T, Hamamori Y, et al. Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3. J Biol Chem. 2008;283:19176-83 pubmed publisher
Wei G, Defeo K, Hayes C, Woster P, Mandik Nayak L, Gilmour S. Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008;68:2214-22 pubmed publisher
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa Saito M, et al. Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1. Mol Biol Cell. 2008;19:1007-21 pubmed
Lai C, Jeng K, Machida K, Cheng Y, Lai M. Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation. Virology. 2008;370:295-309 pubmed
Wood J, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007;282:35416-23 pubmed
Sun Y, Xu Y, Roy K, Price B. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007;27:8502-9 pubmed
Iwahori S, Shirata N, Kawaguchi Y, Weller S, Sato Y, Kudoh A, et al. Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein. J Virol. 2007;81:9653-64 pubmed
Fernandes N, Sun Y, Price B. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007;282:16577-84 pubmed
Inoue Y, Kitagawa M, Taya Y. Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J. 2007;26:2083-93 pubmed
Stauffer D, Chang B, Huang J, Dunn A, Thayer M. p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. J Biol Chem. 2007;282:9678-87 pubmed
Shi Y, Dodson G, Mukhopadhyay P, Shanware N, Trinh A, Tibbetts R. Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies. J Biol Chem. 2007;282:9236-43 pubmed
Geng L, Zhang X, Zheng S, Legerski R. Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B. Mol Cell Biol. 2007;27:2625-35 pubmed
Gueven N, Chen P, Nakamura J, Becherel O, Kijas A, Grattan Smith P, et al. A subgroup of spinocerebellar ataxias defective in DNA damage responses. Neuroscience. 2007;145:1418-25 pubmed
Shanware N, Trinh A, Williams L, Tibbetts R. Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage. J Biol Chem. 2007;282:6283-91 pubmed
Ahmed K, Dong S, Fan M, Li J. Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells. Mol Cancer Res. 2006;4:945-55 pubmed
Shreeram S, Hee W, Demidov O, Kek C, Yamaguchi H, Fornace A, et al. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med. 2006;203:2793-9 pubmed
Kirshner J, Jobling M, Pajares M, Ravani S, Glick A, Lavin M, et al. Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. Cancer Res. 2006;66:10861-9 pubmed
Henderson M, Munoz M, Saunders D, Clancy J, Russell A, Williams B, et al. EDD mediates DNA damage-induced activation of CHK2. J Biol Chem. 2006;281:39990-40000 pubmed
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y. DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. J Cell Sci. 2006;119:4644-9 pubmed
Bai L, Kao J, Law D, Merchant J. Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. Gastroenterology. 2006;131:841-52 pubmed
Shreeram S, Demidov O, Hee W, Yamaguchi H, Onishi N, Kek C, et al. Wip1 phosphatase modulates ATM-dependent signaling pathways. Mol Cell. 2006;23:757-64 pubmed
Wu X, Shell S, Liu Y, Zou Y. ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Oncogene. 2007;26:757-64 pubmed
Kozlov S, Graham M, Peng C, Chen P, Robinson P, Lavin M. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 2006;25:3504-14 pubmed
Tatsumi Y, Sugimoto N, Yugawa T, Narisawa Saito M, Kiyono T, Fujita M. Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability. J Cell Sci. 2006;119:3128-40 pubmed
Jiang X, Sun Y, Chen S, Roy K, Price B. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006;281:15741-6 pubmed
Gueven N, Becherel O, Birrell G, Chen P, DelSal G, Carney J, et al. Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype. Cancer Res. 2006;66:2907-12 pubmed
Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K. Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006;4:125-33 pubmed
Aglipay J, Martin S, Tawara H, Lee S, Ouchi T. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem. 2006;281:9710-8 pubmed
Wang H, Chou W, Shieh S, Shen C. Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining. Cancer Res. 2006;66:1391-400 pubmed
Gibson S, Bindra R, Glazer P. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005;65:10734-41 pubmed
Dodson G, Tibbetts R. DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM. J Biol Chem. 2006;281:1692-7 pubmed
Shi Y, Dodson G, Shaikh S, Rundell K, Tibbetts R. Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo. J Biol Chem. 2005;280:40195-200 pubmed
Gueven N, Fukao T, Luff J, Paterson C, Kay G, Kondo N, et al. Regulation of the Atm promoter in vivo. Genes Chromosomes Cancer. 2006;45:61-71 pubmed
Sun Y, Jiang X, Chen S, Fernandes N, Price B. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005;102:13182-7 pubmed
Kim J, Krasieva T, Kurumizaka H, Chen D, Taylor A, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005;170:341-7 pubmed
Young D, Jonnalagadda J, Gatei M, Jans D, Meyn S, Khanna K. Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J Biol Chem. 2005;280:27587-94 pubmed
Wang J, Pluth J, Cooper P, Cowan M, Chen D, Yannone S. Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst). 2005;4:556-70 pubmed
Peng Y, Woods R, Beamish H, Ye R, Lees Miller S, Lavin M, et al. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res. 2005;65:1670-7 pubmed
Li J, Stern D. Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem. 2005;280:12041-50 pubmed
Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, et al. Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment. J Biol Chem. 2005;280:8156-63 pubmed
Lai C, Chun H, Nahas S, Mitui M, Gamo K, Du L, et al. Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004;101:15676-81 pubmed
Butch A, Chun H, Nahas S, Gatti R. Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates. Clin Chem. 2004;50:2302-8 pubmed
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story M, Legerski R. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. Mol Cell Biol. 2004;24:9207-20 pubmed
Silverman J, Takai H, Buonomo S, Eisenhaber F, de Lange T. Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. Genes Dev. 2004;18:2108-19 pubmed
Xu X, Lee J, Stern D. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem. 2004;279:34091-4 pubmed
Dodson G, Shi Y, Tibbetts R. DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells. J Biol Chem. 2004;279:34010-4 pubmed
Fabbro M, Savage K, Hobson K, Deans A, Powell S, McArthur G, et al. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. J Biol Chem. 2004;279:31251-8 pubmed
Dork T, Bendix Waltes R, Wegner R, Stumm M. Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations. Am J Med Genet A. 2004;126A:272-7 pubmed
Fujiuchi N, Aglipay J, Ohtsuka T, Maehara N, Sahin F, Su G, et al. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem. 2004;279:20339-44 pubmed
Panta G, Kaur S, Cavin L, Cortes M, Mercurio F, Lothstein L, et al. ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage. Mol Cell Biol. 2004;24:1823-35 pubmed
Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean N, et al. Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation. Genes Dev. 2004;18:249-54 pubmed
Qi J, Shackelford R, Manuszak R, Cheng D, Smith M, Link C, et al. Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo. Gene Ther. 2004;11:25-33 pubmed
Huang T, Wuerzberger Davis S, Wu Z, Miyamoto S. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell. 2003;115:565-76 pubmed
Naka K, Tachibana A, Ikeda K, Motoyama N. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem. 2004;279:2030-7 pubmed
Shackelford R, Manuszak R, Johnson C, Hellrung D, Steele T, Link C, et al. Desferrioxamine treatment increases the genomic stability of Ataxia-telangiectasia cells. DNA Repair (Amst). 2003;2:971-81 pubmed
Gueven N, Keating K, Fukao T, Loeffler H, Kondo N, Rodemann H, et al. Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation. Genes Chromosomes Cancer. 2003;38:157-67 pubmed
Cortés M, Bakkenist C, Di Maria M, Kastan M, Breakefield X. HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype. Gene Ther. 2003;10:1321-7 pubmed
Fedier A, Schlamminger M, Schwarz V, Haller U, Howell S, Fink D. Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites. Ann Oncol. 2003;14:938-45 pubmed
Kozlov S, Gueven N, Keating K, Ramsay J, Lavin M. ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. J Biol Chem. 2003;278:9309-17 pubmed
Kim J, Krasieva T, LaMorte V, Taylor A, Yokomori K. Specific recruitment of human cohesin to laser-induced DNA damage. J Biol Chem. 2002;277:45149-53 pubmed
Zhou X, Wang X, Wang H, Chen D, Li G, Iliakis G, et al. Ku affects the ATM-dependent S phase checkpoint following ionizing radiation. Oncogene. 2002;21:6377-81 pubmed
Girard P, Riballo E, Begg A, Waugh A, Jeggo P. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene. 2002;21:4191-9 pubmed
Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, et al. Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM. J Biol Chem. 2002;277:30515-23 pubmed
Scott S, Bendix R, Chen P, Clark R, Dork T, Lavin M. Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer. Proc Natl Acad Sci U S A. 2002;99:925-30 pubmed
Perkins E, Nair A, Cowley D, van Dyke T, Chang Y, Ramsden D. Sensing of intermediates in V(D)J recombination by ATM. Genes Dev. 2002;16:159-64 pubmed
Dork T, Bendix R, Bremer M, Rades D, Klöpper K, Nicke M, et al. Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients. Cancer Res. 2001;61:7608-15 pubmed
Smilenov L, Brenner D, Hall E. Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells. Cancer Res. 2001;61:5710-3 pubmed
Weil M, Kittrell F, Yu Y, McCarthy M, Zabriskie R, Ullrich R. Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice. Oncogene. 2001;20:4409-11 pubmed
Vemuri M, Schiller E, Naegele J. Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice. Cell Death Differ. 2001;8:245-55 pubmed
Hu B, Zhou X, Wang X, Zeng Z, Iliakis G, Wang Y. The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway. J Biol Chem. 2001;276:17693-8 pubmed
Scherthan H, Jerratsch M, Dhar S, Wang Y, Goff S, Pandita T. Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice. Mol Cell Biol. 2000;20:7773-83 pubmed
Wang Y, Cortez D, Yazdi P, Neff N, Elledge S, Qin J. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 2000;14:927-39 pubmed
Borghesani P, Alt F, Bottaro A, Davidson L, Aksoy S, Rathbun G, et al. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A. 2000;97:3336-41 pubmed
product information
Catalog No :
GTX70103
Product Name :
ATM antibody [2C1]
Host Species :
Mouse
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
100.00μg
List Price :
299 USD
list of Pubmed id :
11799059,18846213,17074762,21889946,14681694,21137054,11479203,23337116,16513843,16835273,14651848,17426037,11003672,19147735,20080624,21460856,17380128,12796033,21227757,12034743,15811628,17242184,15054841,16432227,20356374,15753361,18162579,22566699,19783983,18424439,20123963,20026654,20876283,14871926,18593932,15929992,11606401,19339550,15486025,19959400,22213803,22431734,19261750,15498871,16061690,16603769,23028957,19808974,17925396,21193212,16141325,18922873,22563078,16452482,11278490,16540636,22451927,17158963,18337245,14570874,16221684,12645530,20048340,23211021,18971944,15220350,21150274,11805335,20676049,22187663,17189385,11466622,21301226,11319607,22055193,17923702,20678261,18667510,21911475,20730097,16322218,23303793,16949371,18381427,10783165,18820287,15668230,20395202,10716718,23157317,17272271,22529335,21149446,20861182,15159397,16858402,21421559,15197179,17609267,17671184,15456891,20019063,17090522,23178371,20304914,16452194,15611093,23437304,16862173,22493284,21219611,12228239,21705321,19803747,12883528,14990579,22693253,21937426,17244605,14966265,12082606,20194434,15342490,17062639,19242509,22972376,12967654,21576354,12939743,20679231,16180236,16952553,17224243,17931678,23525106,23667485,12214278,16293623,17209043,18442975,21757780,23197857,23474819,23878245,23890999,24342190,24662822,24933654,25105411,25113059,24763056,25240135,25533949,25535335,25770783,25757624,25826455
Clone :
2C1
Isotype :
IgG1
Product Description :
Mouse monoclonal antibody [2C1] to ATM
CrossReactivity :
Hu, Ms, Mk, Rat
Background :
The ATM antibody, clone 2C1, recognizes full-length ATM, a 370kDa nuclear phosphoprotein, which is involved in the autosomal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigation.
Immunogen :
Recombinant protein expressed in E. coli corresponding to amino acids 2577-3056.
Buffer :
Phosphate-buffered saline, pH 7.4, containing no preservatives
Uses :
ELISA, FACS, ICC/IF, IHC-P, IP, WB, ChIP assay
Concentration :
1mg/ml
General References :
Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
Image Legend_4 :
Detection of human ATM protein using anti-ATM 2C1 monoclonal antibody (GTX70103) by western blot or immunoprecipitation.
Image Legend_5 :
Detection of ATM (Anti-ATM 2C1, GTX70103) or ATR (Anti-ATR 2B5,GTX70109) by western blot in human Raji whole cell extract.
Image Legend_6 :
ATM antibody [2C1] detects ATM protein by western blot analysis. A. 30 μg U87-MG whole cell lysate/extract . B. 30 μg SK-N-SH whole cell lysate/extract . C. 30 μg IMR32 whole cell lysate/extract . D. 30 μg SK-N-AS whole cell lysate/extract. 5 % SDS-PAGE. ATM antibody [2C1] (GTX70103) dilution: 1:1000
more info or order :
GeneTex product webpage
company information
GeneTex
2456 Alton Pkwy
Irvine, CA92606
info@genetex.com
http://www.genetex.com
1-877-436-3839
headquarters: USA