MEK2 antibody [GT3522] | GeneTex GTX630543 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

MEK2 antibody [GT3522]

catalog :

GTX630543

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

GTX630543

Product Name :

MEK2 antibody [GT3522]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary Antibody

Background :

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq]