ATRX antibody [GT4212] | GeneTex GTX629703 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

ATRX antibody [GT4212]

catalog :

GTX629703

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

citations: 1

Reference
Napier C, Huschtscha L, Harvey A, Bower K, Noble J, Hendrickson E, et al. ATRX represses alternative lengthening of telomeres. Oncotarget. 2015;6:16543-58 pubmed

product information

Catalog Number :

GTX629703

Product Name :

ATRX antibody [GT4212]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary Antibody

list of Pubmed id :

26001292

Background :

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]