p21 Cip1 antibody [GT8611] | GeneTex GTX629627 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

p21 Cip1 antibody [GT8611]

catalog :

GTX629627

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

GTX629627

Product Name :

p21 Cip1 antibody [GT8611]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary Antibody

Background :

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]