p21 Cip1 antibody [GT1032] | GeneTex GTX629543 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

p21 Cip1 antibody [GT1032]

catalog :

GTX629543

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GT1032

reactivity :

human

citations: 4

Reference
Huang L, Tam K, Liu W, Lin C, Hsu K, Hsieh W, et al. CRISPR/Cas9 Genome Editing of Epidermal Growth Factor Receptor Sufficiently Abolished Oncogenicity in Anaplastic Thyroid Cancer. Dis Markers. 2018;2018:3835783 pubmed publisher
Hsu K, Huang C, Tam K, Lin C, Huang L, Lin C, et al. The Application of Non-Invasive Apoptosis Detection Sensor (NIADS) on Histone Deacetylation Inhibitor (HDACi)-Induced Breast Cancer Cell Death. Int J Mol Sci. 2018;19: pubmed publisher
Chung C, Leung K, Lu W, Yen T, He C, Sheu J, et al. Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes. Evid Based Complement Alternat Med. 2015;2015:595824 pubmed publisher
Chang T, Hsu M, Wu K. High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy. PLoS ONE. 2015;10:e0126537 pubmed publisher

product information

Catalog Number :

GTX629543

Product Name :

p21 Cip1 antibody [GT1032]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary Antibody

list of Pubmed id :

26379747,25961745

Background :

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq]