Lamin A + C antibody [GT9712] | GeneTex GTX629404 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

Lamin A + C antibody [GT9712]

catalog :

GTX629404

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

GTX629404

Product Name :

Lamin A + C antibody [GT9712]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary Antibody

Background :

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq]