TET1 antibody [GT1462] | GeneTex GTX627420 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

TET1 antibody [GT1462]

catalog :

GTX627420

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GT1462

reactivity :

human, pig

application :

immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

GeneTex product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; pig; 1:200; loading ...; fig s3d	Kobayashi T, Zhang H, Tang W, Irie N, Withey S, Klisch D, et al. Principles of early human development and germ cell program from conserved model systems. Nature. 2017;546:416-420 pubmed publisher
immunocytochemistry; human; 1:250; fig 3ef	Irie N, Weinberger L, Tang W, Kobayashi T, Viukov S, Manor Y, et al. SOX17 is a critical specifier of human primordial germ cell fate. Cell. 2015;160:253-68 pubmed publisher
	Li Q, Yi B, Feng Z, Meng R, Tian C, Xu Q. FAM20C could be targeted by TET1 to promote odontoblastic differentiation potential of human dental pulp cells. Cell Prolif. 2018;51:e12426 pubmed publisher
	Verma N, Pan H, Dore L, Shukla A, Li Q, Pelham Webb B, et al. TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells. Nat Genet. 2018;50:83-95 pubmed publisher
	Jiang X, Hu C, Ferchen K, Nie J, Cui X, Chen C, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017;8:2099 pubmed publisher
	Good C, Madzo J, Patel B, Maegawa S, Engel N, Jelinek J, et al. A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer. Nucleic Acids Res. 2017;45:8269-8281 pubmed publisher
	Pei Y, Lei Y, Liu X. MiR-29a promotes cell proliferation and EMT in breast cancer by targeting ten eleven translocation 1. Biochim Biophys Acta. 2016;1862:2177-2185 pubmed publisher
	Rao L, Yi B, Li Q, Xu Q. TET1 knockdown inhibits the odontogenic differentiation potential of human dental pulp cells. Int J Oral Sci. 2016;8:110-6 pubmed publisher
	Yang Y, Zhao J, Fong K, Kim J, Li S, Song C, et al. FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function. Nucleic Acids Res. 2016;44:8153-64 pubmed publisher
	Li Q, Rao L, Zhang D, Xu Q. Expression features of DNA methylcytosine dioxygenase ten-eleven translocation 1 in human dental pulp cells. J Endod. 2014;40:1791-5 pubmed publisher
	Loriot A, Van Tongelen A, Blanco J, Klaessens S, Cannuyer J, van Baren N, et al. A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. Epigenetics. 2014;9:1163-71 pubmed publisher
	Mahaira L, Katsara O, Pappou E, Iliopoulou E, Fortis S, Antsaklis A, et al. IGF2BP1 expression in human mesenchymal stem cells significantly affects their proliferation and is under the epigenetic control of TET1/2 demethylases. Stem Cells Dev. 2014;23:2501-12 pubmed publisher

product information

Catalog Number :

GTX627420

Product Name :

TET1 antibody [GT1462]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary Antibody

list of Pubmed id :

24915579,25179935,25543152,27257062,27357322,27555295,25089631,29235481,29203910,29277934

Background :

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

more info or order :

GeneTex product webpage