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product summary
company name :
GeneTex
product type :
antibody
product name :
Estrogen Receptor alpha antibody [EPR4097]
catalog :
GTX62423
quantity :
100.00μl
price :
329 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
EPR4097
reactivity :
human
application :
western blot, immunocytochemistry, FACS, immunohistochemistry - paraffin section
product information
Catalog No :
GTX62423
Product Name :
Estrogen Receptor alpha antibody [EPR4097]
Host Species :
Rabbit
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
100.00μl
List Price :
329 USD
Clone :
EPR4097
Isotype :
IgG
Product Description :
Rabbit monoclonal antibody [EPR4097] to ER alpha
CrossReactivity :
Hu
Background :
Estrogen receptor alpha (ER alpha) is a ligand-activated transcription factor and member of the steroid hormone receptor family. It possesses highly conserved DNA binding and ligand binding domains for hormone binding, exerting a significant role in activating the transcription of certain genes . ER alpha binds to estrogen response elements (ERE) to regulate estrogen-responsive gene expression . Ligand-dependent dimerization and phosphorylation both function to regulate the transcriptional activation of ER alpha . Phosphorylation of serines 104 and 106, located in the N-terminal transcription activation function-1 domain (AF-1), regulates ER alpha activity . It is a prognostic marker for breast cancer because ER alpha is present in the mammary gland .
Immunogen :
A recombinant human ER alpha protein was used as an immunogen.
Buffer :
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Uses :
FACS, ICC/IF, IHC-P, WB, ChIP assay
General References :
Store at -20 °C. Stable for 12 months from date of receipt.
company information
GeneTex
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