STAT3 (phospho Tyr705) antibody [EP2147Y] | GeneTex GTX61820 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

STAT3 (phospho Tyr705) antibody [EP2147Y]

catalog :

GTX61820

quantity :

100.00μl

price :

329 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

EP2147Y

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

GeneTex product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat; fig 6 western blot; rat; fig 5	Li P, Sheu M, Ma W, Pan C, Sheu J, Wu C. Anti-Restenotic Roles of Dihydroaustrasulfone Alcohol Involved in Inhibiting PDGF-BB-Stimulated Proliferation and Migration of Vascular Smooth Muscle Cells. Mar Drugs. 2015;13:3046-60 pubmed publisher
	Yang D, Chang Y, Lin H, Chen Y, Hsu S, Lin J. Inhibitory effect of litchi (Litchi chinensis Sonn.) flower on lipopolysaccharide-induced expression of proinflammatory mediators in RAW264.7 cells through NF-κB, ERK, and JAK2/STAT3 inactivation. J Agric Food Chem. 2014;62:3458-65 pubmed publisher

image

image 1 :

C. Immunofluorescent staining of HeLa cells using anti-Phospho STAT3 (pY705) RabMAb (cat. # GTX61820)

image 2 :

B. Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using anti-Phospho STAT3 (pY705) RabMAb (cat. # GTX61820).

image 3 :

A. Western blot analysis on HeLa cell lysates using anti-Phospho-Stat3 (pY705) RabMAb (cat. #GTX61820) 1:20000 dilution. Cells were either (A) untreated (B) treated with IFN-alpha.

product information

Catalog No :

GTX61820

Product Name :

STAT3 (phospho Tyr705) antibody [EP2147Y]

Host Species :

Rabbit

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

100.00μl

List Price :

329 USD

list of Pubmed id :

24641487

Clone :

EP2147Y

Isotype :

IgG

Product Description :

Rabbit monoclonal antibody [EP2147Y] to Stat-3 (phospho Tyr705)

CrossReactivity :

Hu, Ms, Rat

Background :

Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors . Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus . Stat3 is constitutively activated in a number of human tumors . Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding Meanwhile, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 .

Immunogen :

A synthetic phospho-peptide corresponding to residues surrounding tyrosine 705 of human Stat3 was used as immunogen.

Buffer :

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Uses :

ICC/IF, IHC-P, IP, WB

General References :

Store at -20 °C. Stable for 12 months from date of receipt.

more info or order :

GeneTex product webpage