This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
FAK (phospho Tyr397) antibody [EP2160Y]
catalog :
GTX61795
quantity :
100.00μl
price :
329 USD
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
EP2160Y
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
product information
Catalog No :
GTX61795
Product Name :
FAK (phospho Tyr397) antibody [EP2160Y]
Host Species :
Rabbit
Clonality :
Monoclonal
Antigen Modification :
Phosphorylated
Product Type :
Primary antibody
Size :
100.00μl
List Price :
329 USD
Clone :
EP2160Y
Isotype :
IgG
Product Description :
Rabbit monoclonal antibody [EP2160Y] to FAK (phospho Tyr397)
CrossReactivity :
Hu, Ms, Rat
Background :
Focal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis . FAK is composed of a central catalytic domain flanked by large N- and C-terminal regions. FAK is activated by phosphorylation at tyrosine 397 in response to integrin clustering which can be induced by cell adhesion or antibody cross-linking or via G-protein-coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid . Phosphorylation of FAK Tyr-397 creates a binding site for Src-family kinases, and phosphorylation of FAK Tyr-576/Tyr-577 in the kinase domain activation loop enhances catalytic activity . Increased FAK expression has been correlated with the enhanced motility and invasiveness of human tumor cells, as well as with promoting increased cell proliferation.
Immunogen :
A phospho-specific peptide corresponding to residues surrounding Tyrosine 397 of human FAK was used as an immunogen.
Specificity :
This antibody detects FAK phosphorylated at Y397.
Buffer :
PBS containing 50% Glycerol, 0.05% BSA and 0.01% Sodium azide.
Uses :
ICC/IF, WB
General References :
Store at -20 °C. Stable for 12 months from date of receipt.
company information
GeneTex
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