ATM (phospho Ser1981) antibody [EP1890Y] | GeneTex GTX61739 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

ATM (phospho Ser1981) antibody [EP1890Y]

catalog :

GTX61739

quantity :

100.00μl

price :

329 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

EP1890Y

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

GeneTex product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:1000; loading ...; fig 1b	Chen C, Tsao N, Huang L, Yen Y, Liu X, Lehman C, et al. The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells. Cell Rep. 2016;16:1287-1299 pubmed publisher
western blot; human; fig 6	Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen J, et al. RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence. Mol Biol Cell. 2016;27:1346-57 pubmed publisher
western blot; human	Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed publisher
	Jones G, Rooney C, Griffin N, Roudier M, Young L, Garcia Trinidad A, et al. pRAD50: a novel and clinically applicable pharmacodynamic biomarker of both ATM and ATR inhibition identified using mass spectrometry and immunohistochemistry. Br J Cancer. 2018;119:1233-1243 pubmed publisher
	Cheung C, Singh R, Kalra R, Kaul S, Wadhwa R. Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. J Biol Chem. 2014;289:18258-69 pubmed publisher
	Huang F, Chang C, Wang J, Chang T, Lin J. Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br J Pharmacol. 2012;167:393-406 pubmed publisher

product information

Catalog No :

GTX61739

Product Name :

ATM (phospho Ser1981) antibody [EP1890Y]

Host Species :

Rabbit

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

100.00μl

List Price :

329 USD

list of Pubmed id :

22509942,24825908,25105411

Clone :

EP1890Y

Isotype :

IgG

Product Description :

Rabbit monoclonal antibody [EP1890Y] to ATM (phospho Ser1981)

CrossReactivity :

Background :

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]

Immunogen :

A synthetic peptide corresponding to residues surrounding serine 1981 of human ATM was used as an immunogen.

Buffer :

PBS containing 50% Glycerol, 0.05% BSA and 0.01% Sodium azide.

Uses :

ICC/IF, IHC, IHC-P, IP, WB

General References :

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

more info or order :

GeneTex product webpage