MMP14 antibody [EP1264Y] | GeneTex GTX61603 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

MMP14 antibody [EP1264Y]

catalog :

GTX61603

quantity :

100.00μl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EP1264Y

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, FACS, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200; tbl 2	Cid S, Eiró N, Gonzalez L, Béridze N, Vazquez J, Vizoso F. Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas. Clin Breast Cancer. 2016;16:e83-91 pubmed publisher
	Nakazawa Y, Taniyama Y, Sanada F, Morishita R, Nakamori S, Morimoto K, et al. Periostin blockade overcomes chemoresistance via restricting the expansion of mesenchymal tumor subpopulations in breast cancer. Sci Rep. 2018;8:4013 pubmed publisher
	Sandner A, Illert J, Koitzsch S, Unverzagt S, Schön I. Reflux induces DNA strand breaks and expression changes of MMP1+9+14 in a human miniorgan culture model. Exp Cell Res. 2013;319:2905-15 pubmed publisher
	Kudo L, Parfenova L, Vi N, Lau K, Pomakian J, Valdmanis P, et al. Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis. Hum Mol Genet. 2010;19:3233-53 pubmed publisher

product information

Catalog No :

GTX61603

Product Name :

MMP14 antibody [EP1264Y]

Host Species :

Rabbit

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

list of Pubmed id :

20530642,24075964

Clone :

EP1264Y

Isotype :

IgG

Product Description :

Rabbit monoclonal antibody [EP1264Y] to MMP-14

CrossReactivity :

Hu, Ms, Rat

Background :

The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix . Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumor stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface . Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) .

Immunogen :

It is raised against a short peptide, which maps between amino acids 160~190 of human MMP-14 (Uniprot:P50281).

Buffer :

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Uses :

FACS, ICC/IF, IHC-P, IP, WB

General References :

Store at -20 °C. Stable for 12 months from date of receipt.