beta Catenin antibody [E247] | GeneTex GTX61089 product information

product summary

company name :

GeneTex

product type :

antibody

product name :

beta Catenin antibody [E247]

catalog :

GTX61089

quantity :

100.00μl

price :

329 USD

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

E247

The same clone is also sold as:

BioLogo: CTN001-G
Invitrogen: MA5-14461

reactivity :

human, mouse, rat, cow

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

GeneTex product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 6a	Chang L, Chen T, Chen S, Chen C, Lee C, Wu S, et al. Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation. Oncotarget. 2016;7:67986-68001 pubmed publisher
western blot; human; 1:1000	Wang J, Huang F, Kuo M, Wang Z, Tseng T, Chang L, et al. Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers. J Biol Chem. 2014;289:14612-23 pubmed publisher
	Shaked H, Hofseth L, Chumanevich A, Chumanevich A, Wang J, Wang Y, et al. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci U S A. 2012;109:14007-12 pubmed publisher

image

image 1 :

ICC/IF analysis of A431 cells using beta Catenin antibody [E247] at a dilution of 1:250.

image 2 :

IHC-P analysis of IHC analysis of human colon adenocarcinoma tissue using beta Catenin antibody [E247] at a dilution of 1:500.

image 3 :

IHC analysis of kidney carcinoma tissue using beta Catenin antibody [E247].

product information

Catalog No :

GTX61089

Product Name :

beta Catenin antibody [E247]

Host Species :

Rabbit

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

329 USD

list of Pubmed id :

22893683,24713700

Clone :

E247

Isotype :

IgG

Product Description :

Rabbit monoclonal antibody [E247] to beta Catenin

CrossReactivity :

Hu, Ms, Cow, Mk, Rat, Hm, Shp

Background :

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]

Immunogen :

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to Human beta Catenin aa 1-100 (N terminal).

Buffer :

PBS containing 50% Glycerol, 0.05% BSA and 0.01% Sodium azide.

Uses :

ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB

Concentration :

0.029mg/ml

General References :

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

more info or order :

GeneTex product webpage