This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
p14ARF antibody [1D7D2]
catalog :
GTX60663
quantity :
100.00μl
price :
289 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1D7D2
reactivity :
human
application :
western blot, ELISA, FACS, immunohistochemistry - paraffin section
product information
Catalog No :
GTX60663
Product Name :
p14ARF antibody [1D7D2]
Host Species :
Mouse
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
100.00μl
List Price :
289 USD
Clone :
1D7D2
Isotype :
IgG1
Product Description :
Mouse monoclonal antibody [1D7D2] to p14ARF
CrossReactivity :
Hu
Background :
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 cont
Immunogen :
The immunogen corresponding to a region within amino acids 1 and 156 of human CDKN2A expressed in E. Coli.
Buffer :
Ascitic fluid containing 0.03% sodium azide.
Uses :
ELISA, FACS, IHC-P, WB
General References :
4°C; -20°C for long term storage
Image Legend_4 :
Red: Control Antigen (100ng);
Purple: Antigen (10ng);
Green: Antigen (50ng);
Blue: Antigen (100ng);
Image Legend_5 :
WB analysis of human p14ARF recombinant protein using p14ARF antibody [1D7D2].
Image Legend_6 :
IHC-P analysis of endometrial cancer tissue using p14ARF antibody [1D7D2].
company information
GeneTex
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