GluR2 (phospho Ser880) antibody | GeneTex GTX52325 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

GluR2 (phospho Ser880) antibody

catalog :

GTX52325

quantity :

100.00μg

price :

289 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog No :

GTX52325

Product Name :

GluR2 (phospho Ser880) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

100.00μg

List Price :

289 USD

Isotype :

IgG

Product Description :

Rabbit Polyclonal antibody to GluR2 (phospho Ser880)

CrossReactivity :

Hu, Ms, Rat

Background :

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG- Q- R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been no

Immunogen :

A synthesized peptide derived from human GluR2 around the phosphorylation site of Ser880

Specificity :

GRIA2

Buffer :

phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Uses :

IHC, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.