p38 MAPK (phospho Tyr182) antibody | GeneTex GTX50281 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

p38 MAPK (phospho Tyr182) antibody

catalog :

GTX50281

quantity :

100.00μl

price :

299 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Rampanelli E, Dessing M, Claessen N, Teske G, Joosten S, Pals S, et al. CD44-deficiency attenuates the immunologic responses to LPS and delays the onset of endotoxic shock-induced renal inflammation and dysfunction. PLoS ONE. 2013;8:e84479 pubmed publisher

product information

Catalog No :

GTX50281

Product Name :

p38 MAPK (phospho Tyr182) antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Product Type :

Primary antibody

Size :

100.00μl

List Price :

299 USD

list of Pubmed id :

24376813

Product Description :

Rabbit polyclonal antibody to p38 MAPK (phospho Tyr182)

CrossReactivity :

Hu, Ms, Rat

Background :

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Immunogen :

Peptide sequence around phosphorylation site of tyrosine 182 (T-G-Y(p)-V-A) derived from Human P38 MAPK.

Buffer :

saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Uses :

IHC, IHC-P, WB

Concentration :

1mg/ml

General References :

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Image Legend_4 :

WB analysis of lysates from HeLa cells treated with TNFa or calf intestinal phosphatase (CIP) using p38 MAPK (phospho Tyr182) antibody.