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product summary
company name :
GeneTex
product type :
antibody
product name :
AKT (phospho Ser473) antibody
catalog :
GTX50128
quantity :
100.00μl
price :
299 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
product information
Catalog No :
GTX50128
Product Name :
AKT (phospho Ser473) antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen Modification :
Phosphorylated
Product Type :
Primary antibody
Size :
100.00μl
List Price :
299 USD
Product Description :
Rabbit Polyclonal antibody to Akt (Phospho Ser473)
CrossReactivity :
Hu, Ms, Rat
Background :
General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.
Immunogen :
Peptide sequence around phosphorylation site of serine 473 (Q-F-S(p)-Y-S) derived from Human Akt.
Buffer :
saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Uses :
IHC, IHC-P, WB
Concentration :
1mg/ml
General References :
Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
company information
GeneTex
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