ALIX antibody [3A9] | GeneTex GTX42812 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

ALIX antibody [3A9]

catalog :

GTX42812

quantity :

100.00μg

price :

329 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A9

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 1

Reference
May E, Lin S, Lin C, Chang J, Hung E, Lo Y, et al. Identification of up- and down-regulated proteins in doxorubicin-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance. Pharmacol Res. 2014;90:1-17 pubmed publisher

product information

Catalog No :

GTX42812

Product Name :

ALIX antibody [3A9]

Host Species :

Mouse

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

100.00μg

List Price :

329 USD

list of Pubmed id :

25242635,25242635

Clone :

3A9

Isotype :

IgG1

Product Description :

Mouse monoclonal antibody [3A9] to ALIX

CrossReactivity :

Hu, Ms, Rat, Xl

Background :

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

Immunogen :

Alix fusion protein.

Specificity :

This antibody recognizes the apoptosis-linked gene-2 interacting protein X (ALIX). Clone 3A9 has been used extensively for the detection of ALIX by Western blotting and for the identification of an ALIX homologue in the sea urchin Paracentrotus lividus (R

Buffer :

Phosphate buffered saline containing 0.09% Sodium Azide (NaN3)

Uses :

ELISA, ICC/IF, IHC-P, IP, WB

General References :

Store at +4°C or at -20°C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.