CD3 antibody [CD3-12] | GeneTex GTX42110 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

CD3 antibody [CD3-12]

catalog :

GTX42110

quantity :

25.00μg

price :

199 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

CD3-12

reactivity :

human, mouse, dog, chicken

application :

western blot, ELISA, immunocytochemistry, FACS, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Catalog No :

GTX42110

Product Name :

CD3 antibody [CD3-12]

Host Species :

Rat

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

25.00μg

List Price :

199 USD

Clone :

CD3-12

Isotype :

IgG1

Product Description :

Rat monoclonal antibody [CD3-12] to CD3

CrossReactivity :

Hu, Ms, Chk, Dog, Pig, Cat, Duck, Hrs, Owl, Xl, Bov, RMK, ClMK, frg, Raccoon

Background :

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Immunogen :

Synthetic peptide sequence derived from cytoplasmic epitope of CD3 (Glu-Arg-Pro-Pro-Pro-Val-Pro-Asn-Pro-Asp-Tyr-Glu-Pro-Cys) (ERPPPVPNPDYEPC )

Specificity :

Clone CD3-12 has been specifically raised against an epitope within the epsilon peptide chain, highly conserved among species clone CD3-12 has a very broad species crossreactivity for the CD3 marker. (Jones et al. 1993; Kothlow et al. 2005)

Buffer :

Phosphate buffered saline containing 0.09% Sodium Azide

Uses :

ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB

General References :

Store at +4°C or at -20°C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Image Legend_4 :

Formalin fixed, paraffin embedded human tonsil stained with Rat anti Human CD3 (GTX42110) following heat mediated antigen retrieval in EDTA buffer pH9.0

Image Legend_5 :

WB analysis of Jurkat lysate using CD3 antibody [CD3-12].