Collagen I antibody | GeneTex GTX41286 product information

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product summary

company name :

GeneTex

product type :

antibody

product name :

Collagen I antibody

catalog :

GTX41286

quantity :

100.00μl

price :

289 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunocytochemistry, radioimmunoassay, immunohistochemistry - paraffin section

citations: 4

Reference
Dessing M, Tammaro A, Pulskens W, Teske G, Butter L, Claessen N, et al. The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion. Kidney Int. 2015;87:85-94 pubmed publisher
Duitman J, Borensztajn K, Pulskens W, Leemans J, Florquin S, Spek C. CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy. Lab Invest. 2014;94:89-97 pubmed publisher
Rampanelli E, Rouschop K, Claessen N, Teske G, Pals S, Leemans J, et al. Opposite role of CD44-standard and CD44-variant-3 in tubular injury and development of renal fibrosis during chronic obstructive nephropathy. Kidney Int. 2014;86:558-69 pubmed publisher
Leemans J, Butter L, Pulskens W, Teske G, Claessen N, van der Poll T, et al. The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. PLoS ONE. 2009;4:e5704 pubmed publisher

product information

Catalog No :

GTX41286

Product Name :

Collagen I antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

289 USD

list of Pubmed id :

24247561,19479087,24717295,24940802

Isotype :

IgG

Product Description :

Rabbit polyclonal to Collagen I

CrossReactivity :

Hu, Ms

Background :

Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three dimensional epitopes. This preparation results in a native conformation of the protein.Type I collagen (95 kDa) is found in bone, cornea, skin and tendon.Mutations in the gene encoding collagen 1 are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Immunogen :

Collagen type I extracted and purified from mouse skin.

Specificity :

This antibody is specific to Mouse Collagen Type I (100%) by RIA, and typically showed less than 1% reactivity against other types of mouse collagen types (II, III and IV).

Uses :

ELISA, ICC/IF, IHC-P, RIA

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.