NOTCH1 antibody | GeneTex GTX28925 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

NOTCH1 antibody

catalog :

GTX28925

quantity :

100.00μl

price :

259 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section

citations: 3

Reference
Chu P, Wang Y, Chen I, Pan H, Wu G. Notch 1 signaling pathway effect on implantation competency. Fertil Steril. 2011;96:1225-9 pubmed publisher
Nwabo Kamdje A, Bassi G, Pacelli L, Malpeli G, Amati E, Nichele I, et al. Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Blood Cancer J. 2012;2:e73 pubmed
Cheng X, Huber T, Chen V, Gadue P, Keller G. Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development. 2008;135:3447-58 pubmed publisher

product information

Catalog No :

GTX28925

Product Name :

NOTCH1 antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary antibody

Size :

100.00μl

List Price :

259 USD

list of Pubmed id :

21943726,18799543,22829975

Isotype :

IgG

Product Description :

Rabbit polyclonal to activated Notch1

CrossReactivity :

Hu, Ms, Rat

Background :

Notch is synthesized in the endoplasmic reticulum as an inactive form, which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.

Immunogen :

Peptide: VLLSRKRRRQHGQC (aa1755-1767).This is the N-terminal sequence of the cleaved N intracellular domain (NICD).

Specificity :

Tested in HEK 293 cells with mouse Notch constructs (see Western blot image):Notch-1Does not react with mouse N2, N3 or N4.Only recognises the cleaved intracellular (activated) form (NICD).

Buffer :

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, containing 0.1% sodium azide

Uses :

ELISA, ICC/IF, IHC, IHC-P, Neut, WB

Concentration :

Antiserum

General References :

Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.