This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
Bcl-2 antibody
catalog :
GTX27973
quantity :
1.00 ml
price :
299 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - frozen section
product information
Catalog No :
GTX27973
Product Name :
Bcl-2 antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Product Type :
Primary antibody
Size :
1.00 ml
List Price :
299 USD
Isotype :
IgG
Product Description :
Rabbit polyclonal antibody to Bcl-2
CrossReactivity :
Hu, Ms, Rat
Background :
Bcl-2 family is a key regulator of apoptosis that function to either inhibit or promote cell death. Over expression of members such as Bcl-2 and Bcl-xL inhibit the apoptotic process (1,2). The Bcl-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag-1, for example, has been found to form a heterodimer with Bcl-2 resulting in the enhancement of the anti-apoptotic effect of Bcl-2 (3,4). Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis (6). Bad plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with Bcl-xL, causing the displacement of Bax. The displacement of Bax allows apoptosis to proceed (7). Bcl-xS, a shorter version of Bcl-xL (lacking amino acids 126-188), apparently utilizes a different pathway than Bax to induce cell death. Some research suggests that Bcl-xS uses a novel mechanism for regulating caspase or it may use an alternate cell death effector pathway (8,9).
Immunogen :
Synthetic peptide (Human) (N terminal).
Specificity :
Reacts with Bcl-2
Buffer :
PBS with 0.1% sodium azide and 0.2% gelatin
Uses :
IHC, IHC-Fr, IP, WB
Concentration :
0.2mg/ml
General References :
Store this product at 4 °C, do not freeze. The product is stable for one year from the date of shipment.
company information
GeneTex
questions and comments