This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
GeneTex
product type :
antibody
product name :
NFkB p50 antibody
catalog :
GTX27971
quantity :
1.00 ml
price :
299 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation
product information
Catalog No :
GTX27971
Product Name :
NFkB p50 antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Product Type :
Primary antibody
Size :
1.00 ml
List Price :
299 USD
Isotype :
IgG
Product Description :
Rabbit polyclonal antibody to NFkB p50
CrossReactivity :
Hu, Ms, Rat
Background :
In resting cells, NFkB is retained in the cytoplasm bound to inhibitory proteins of the IkB family. Degradation of IkB proteins occurs with cell activation, via of variety of signals, including inflammatory cytokines and bacterial lipopolysaccharides (LPS) as well as oxidative and fluid mechanical stress. This results in nuclear translocation of NFkB and the transcriptional gene activation of pro-inflammatory genes (1,9). NFkB plays a role in the development of numerous pathological states. Activation of NFkB induces gene programs leading to transcription of factors that promote inflammation, such as leukocyte adhesion molecules, cytokines, and chemokines. It is also thought that there are some substances with possible anti-inflammatory effects that are also NFkappaB regulated. There is some evidence indicating NFkB as a key factor in the pathophysiology of cardiac ischemia-reperfusion injury as well as the development of insulin dependent Diabetes Mellitus (3-4).
Immunogen :
Synthetic peptide (Human) (C terminal).
Specificity :
NFkB p50 (C20) DB035 reacts with NFkB p50 and p105 of mouse, rat, and human origin.
Buffer :
Phosphate-buffered saline containing 0.1% sodium azide and 0.2% gelatin
Uses :
IHC, IP, WB
Concentration :
0.2mg/ml
General References :
Keep as concentrated solution, aliquot and store at 4°C. Do not freeze.
company information
GeneTex
questions and comments